Effects of exercise training on kinin receptors expression in rats with myocardial infarction

被引:5
|
作者
Shen, Mei [1 ]
Yu, Min [1 ]
Li, Jingya [1 ]
Ma, Li [1 ]
机构
[1] Dalian Univ, Dept Rehabil Med, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China
基金
中国国家自然科学基金;
关键词
Angiogenesis; kinin B1 receptor; kinin B2 receptor; exercise training; myocardial infarction; TISSUE KALLIKREIN GENE; MOUSE HEART; BLOOD-PRESSURE; IN-VITRO; ANGIOGENESIS; BRADYKININ; GROWTH; NEOVASCULARIZATION; ARTERIOGENESIS; ISCHEMIA;
D O I
10.1080/13813455.2017.1302962
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Objectives: The objective of this study is to determine the role of kinin B1 and B2 receptors in exercise-induced cardiac muscle angiogenesis. Method: Thirty Wistar rats were randomly assigned to the control group, the myocardial infarction group and the exercise training group (myocardial infarction model was made and received 30 min exercise training on a treadmill). After 4 weeks of experiment, cardiac muscle was harvested. Results: B1 and B2 receptor mRNA and protein levels in the exercise-training group were significantly higher than those in the myocardial infarction group, which were higher than those in the control group. Capillary number in the cardiac muscle also showed the same tendency. There was a correlation between capillary number and B1 receptor protein (not B2 receptor protein) in the all groups. Conclusion: Kinin B1 and B2 receptors play roles in exercise-induced cardiac muscle angiogenesis. However, the B1 receptor appears to have a more prominent role.
引用
收藏
页码:206 / 211
页数:6
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