Knowing what's growing: Why ductal and intraductal prostate cancer matter

被引：25

作者：

Lawrence, Mitchell G. ^{[1
,2
,3
]}

Porter, Laura H. ^{[1
]}

Clouston, David ^{[4
]}

Murphy, Declan G. ^{[3
,5
,6
]}

Frydenberg, Mark ^{[1
,7
,8
]}

Taylor, Renea A. ^{[2
,3
,9
]}

Risbridger, Gail P. ^{[1
,2
,3
]}

机构：

[1] Monash Univ, Monash Biomed Discovery Inst, Dept Anat & Dev Biol,Canc Program, Monash Partners Comprehens Canc Consortium,Prosta, Clayton, Vic 3800, Australia

[2] Peter MacCallum Canc Ctr, Canc Res Div, Melbourne, Vic 3000, Australia

[3] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3010, Australia

[4] TissuPath, Mt Waverley, Vic 3149, Australia

[5] Univ Melbourne, Peter MacCallum Canc Ctr, Div Canc Surg, Melbourne, Vic 3000, Australia

[6] Epworth HealthCare, Melbourne, Vic 3000, Australia

[7] Australian Urol Associates, Melbourne, Vic 3000, Australia

[8] Cabrini Hlth, Dept Urol, Malvern, Vic 3144, Australia

[9] Monash Univ, Monash Biomed Discovery Inst, Dept Physiol,Canc Program, Monash Partners Comprehens Canc Consortium,Prosta, Clayton, Vic 3800, Australia

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2020年 / 12卷 / 533期

基金：

英国医学研究理事会;

关键词：

PATIENT-DERIVED XENOGRAFTS; ISUP CONSENSUS CONFERENCE; GENITAL ORGANS-PART; GLEASON PATTERN 4; INTRAEPITHELIAL NEOPLASIA; NEEDLE-BIOPSY; MOUSE MODELS; PTEN LOSS; CLINICOPATHOLOGICAL CHARACTERISTICS; HISTOPATHOLOGICAL FEATURES;

D O I：

10.1126/scitranslmed.aaz0152

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Prostate cancer is a common malignancy, but only some tumors are lethal. Accurately identifying these tumors will improve clinical practice and instruct research. Aggressive cancers often have distinctive pathologies, including intraductal carcinoma of the prostate (IDC-P) and ductal adenocarcinoma. Here, we review the importance of these pathologies because they are often overlooked, especially in genomics and preclinical testing. Pathology, genomics, and patient-derived models show that IDC-P and ductal adenocarcinoma accompany multiple markers of poor prognosis. Consequently, "knowing what is growing" will help translate preclinical research to pinpoint and treat high-risk prostate cancer in the clinic.

引用

页数：15

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