Immunodeficiencies caused by genetic defects in protein kinases

被引：15
|
作者：
Notarangelo, LD
机构：
[1] Department of Pediatrics, University of Brescia, Brescia
来源：
CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 04期
关键词：
D O I：
10.1016/S0952-7915(96)80028-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The recognition that defects of ZAP-70 and, more recently, of JAK3 kinase in humans result in severe combined immunodeficiency, and the demonstration that targeting of these and other protein-kinase genes in mice also leads to immunodeficiency, have highlighted the crucial role that these proteins play in T-cell differentiation and activation.
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页码：448 / 453
页数：6
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