Highly Efficient Iridium-Catalyzed Asymmetric Hydrogenation of Unprotected β-Enamine Esters

被引：61

作者：

Hou, Guohua ^{[1
]}

Li, Wei ^{[1
]}

Ma, Miaofeng ^{[1
]}

Zhang, Xiaowei ^{[1
]}

Zhang, Xumu ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Chem & Chem Biol & Pharmaceut Chem, Piscataway, NJ 08854 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 37期

基金：

美国国家卫生研究院;

关键词：

ACID-DERIVATIVES; ANTAGONIST; LIGANDS;

D O I：

10.1021/ja105674y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient and enantioselective hydrogenation of unprotected beta-enamine esters catalyzed by Ir-(S,S)-f-Bi-naphane complex has been developed. This methodology provides straightforward access to free beta-amino acids in high yields with excellent enantioselectivities up to 97% ee and high reactivities (TON > 5000).

引用

页码：12844 / 12846

页数：3

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