Hyperexcitability: Exaggerated fear-potentiated startle produced by partial amygdala kindling

被引：73
|
作者：
Rosen, JB
Hamerman, E
Sitcoske, M
Glowa, JR
Schulkin, J
机构：
[1] NIMH,BIOL PSYCHIAT BRANCH,BETHESDA,MD
[2] NIMH,CLIN NEUROENDOCRINOL BRANCH,BETHESDA,MD
[3] NIDDK,MED CHEM LAB,BETHESDA,MD 20892
来源：
BEHAVIORAL NEUROSCIENCE | 1996年 / 110卷 / 01期
关键词：
D O I：
10.1037/0735-7044.110.1.43
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The present study asked whether partial amygdala kindling would affect the expression of conditioned fear-potentiated startle. Rats were conditioned to be fearful of a light. They were then stimulated bilaterally in the amygdala or hippocampus on 2 consecutive days (partial kindling). Rats were tested 24 hr later for fear-potentiated startle. Amygdala-kindled rats had exaggerated fear-potentiated startle compared to sham-kindled rats. Hippocampus-kindled rats also displayed fear-potentiated startle, but no greater than that of sham-kindled rats. Partial amygdala kindling induced c-fos messenger RNA (mRNA) expression, a marker for neuronal activation, throughout the limbic and neocortices. In contrast, partial hippocampus kindling induced c-fos mRNA in the hippocampus only. The data suggest that kindled-induced hyperexcitability of the amygdala and limbic cortices produced exaggerated conditioned fear-potentiated startle.
引用
收藏
页码：43 / 50
页数：8
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