Modeling pulsativity in the hypothalamic-pituitary-adrenal hormonal axis

被引:5
|
作者
Churilov, Alexander N. [1 ]
Milton, John G. [2 ]
机构
[1] St Petersburg State Univ, Fac Math & Mech, St Petersburg, Russia
[2] Claremont Coll, WM Keck Sci Ctr, Claremont, CA 91711 USA
关键词
CORTICOTROPIN-RELEASING HORMONE; HPA AXIS; ADRENOCORTICOTROPIC HORMONE; SECRETION; ANTERIOR; DYNAMICS; CORTISOL; PULSATILITY; SYSTEM; RAT;
D O I
10.1038/s41598-022-12513-w
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A new mathematical model for biological rhythms in the hypothalamic-pituitary-adrenal (HPA) axis is proposed. This model takes the form of a system of impulsive time-delay differential equations which include pulsatile release of adrenocorticotropin (ACTH) by the pituitary gland and a time delay for the release of glucocorticoid hormones by the adrenal gland. Numerical simulations demonstrate that the model's response to periodic and circadian inputs from the hypothalamus are consistent with those generated by recent models which do not include a pulsatile pituitary. In contrast the oscillatory phenomena generated by the impulsive delay equation mode occur even if the time delay is zero. The observation that the time delay merely introduces a small phase shift suggesting that the effects of the adrenal gland are "downstream" to the origin of pulsativity. In addition, the model accounts for the occurrence of ultradian oscillations in an isolated pituitary gland. These observations suggest that principles of pulse modulated control, familiar to control engineers, may have an increasing role to play in understanding the HPA axis.
引用
收藏
页数:9
相关论文
共 50 条
  • [21] The hypothalamic-pituitary-adrenal axis and pathophysiology of hyperadrenocorticism
    Zerbe, CA
    COMPENDIUM ON CONTINUING EDUCATION FOR THE PRACTICING VETERINARIAN, 1999, 21 (12): : 1134 - +
  • [22] THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS IN INFANTILE MALNUTRITION
    MALOZOWSKI, S
    MUZZO, S
    BURROWS, R
    LEIVA, L
    LORIAUX, L
    CHROUSOS, G
    WINTERER, J
    CASSORLA, F
    CLINICAL ENDOCRINOLOGY, 1990, 32 (04) : 461 - 465
  • [23] Effects of cocaine on the hypothalamic-pituitary-adrenal axis
    Manetti, L.
    Cavagnini, F.
    Martino, E.
    Ambrogio, A.
    JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2014, 37 (08): : 701 - 708
  • [24] The hypothalamic-pituitary-adrenal axis in abdominal obesity
    Oliver, C
    Boullu, S
    Darmon, P
    Frachebois, C
    Dadoun, F
    Rosso, JP
    Guillaume, V
    Dutour, A
    Grino, M
    BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE, 1999, 183 (07): : 1455 - 1467
  • [25] Endocannabinoid Signaling and the Hypothalamic-Pituitary-Adrenal Axis
    Hillard, Cecilia J.
    Beatka, Margaret
    Sarvaideo, Jenna
    COMPREHENSIVE PHYSIOLOGY, 2017, 7 (01) : 1 - 15
  • [26] The Hypothalamic-Pituitary-Adrenal Axis: A Brief History
    Miller, Walter L.
    HORMONE RESEARCH IN PAEDIATRICS, 2018, 89 (04): : 212 - 223
  • [27] AGING, INJURY AND THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
    HORAN, MA
    AGING CLOCK: THE PINEAL GLAND AND OTHER PACEMAKERS IN THE PROGRESSION OF AGING AND CARCINOGENESIS, 1994, 719 : 285 - 290
  • [28] THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS IN POSTPARTUM EWES
    SMART, D
    SINGH, I
    SMITH, RF
    FORHEAD, AJ
    DOBSON, H
    ANIMAL REPRODUCTION SCIENCE, 1994, 35 (3-4) : 223 - 229
  • [29] The hypothalamic-pituitary-adrenal axis in critical illness
    Schuetz, Philipp
    Mueller, Beat
    ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2006, 35 (04) : 823 - +
  • [30] Hypothalamic-Pituitary-Adrenal (HPA) Axis and Aging
    Guptaand, Deepashree
    Morley, John E.
    COMPREHENSIVE PHYSIOLOGY, 2014, 4 (04) : 1495 - 1510