Effects of chemical oxidation on the structure, stability, aggregation, and function of an IgG1 mAb

被引:0
|
作者
Shah, Dinen [1 ]
机构
[1] Univ Colorado, Pharmaceut Sci, AMC Campus, Aurora, CO USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
179
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Correlating the Effects of Antimicrobial Preservatives on Conformational Stability, Aggregation Propensity, and Backbone Flexibility of an IgG1 mAb
    Arora, Jayant
    Joshi, Sangeeta B.
    Middaugh, C. Russell
    Weis, David D.
    Volkin, David B.
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 106 (06) : 1508 - 1518
  • [2] Effect of pH and Light on Aggregation and Conformation of an IgG1 mAb
    Mason, Bruce I.
    Schoeneich, Christian
    Kerwin, Bruce A.
    MOLECULAR PHARMACEUTICS, 2012, 9 (04) : 774 - 790
  • [3] Effect of photo-degradation on the structure, stability, aggregation, and function of an IgG1 monoclonal antibody
    Shah, Dinen D.
    Zhang, Jingming
    Maity, Haripada
    Mallela, Krishna M. G.
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2018, 547 (1-2) : 438 - 449
  • [4] Structure and stability changes of human IgG1 Fc as a consequence of methionine oxidation
    Liu, Dingjiang
    Ren, Da
    Huang, Holly
    Dankberg, Jane
    Rosenfeld, Robert
    Cocco, Melanie J.
    Li, Luke
    Brems, David N.
    Remmele, Richard L., Jr.
    BIOCHEMISTRY, 2008, 47 (18) : 5088 - 5100
  • [5] Characterization of Human IgG1 Fc Region Stability and Aggregation Propensity
    Wells, Evan A.
    Robinson, Anne S.
    BIOPHYSICAL JOURNAL, 2017, 112 (03) : 492A - 492A
  • [6] Prediction of IgG1 aggregation in solution
    Ojala, Frida
    Degerman, Marcus
    Hansen, Thomas Budde
    Hansen, Ernst Broberg
    Nilsson, Bernt
    BIOTECHNOLOGY JOURNAL, 2014, 9 (06) : 800 - 804
  • [7] BIOT 460-Stability and structure changes as a consequence of methionine oxidation of IgG1 Fc region
    Liu, Dingjiang
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 236
  • [8] Characterization of the Physical Stability of a Lyophilized IgG1 mAb after Accelerated Shipping-Like Stress
    Telikepalli, Srivalli
    Kumru, Ozan S.
    Kim, Jae Hyun
    Joshi, Sangeeta B.
    O'Berry, Kristin B.
    Blake-Haskins, Angela W.
    Perkins, Melissa D.
    Middaugh, C. Russell
    Volkin, David B.
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, 104 (02) : 495 - 507
  • [9] Effects of Arginine on Photostability and Thermal Stability of IgG1 Monoclonal Antibodies
    Maity, Haripada
    O'Dell, Courtney
    Srivastava, Arvind
    Goldstein, Joel
    CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2009, 10 (08) : 761 - 766
  • [10] Effects of Salts from the Hofmeister Series on the Conformational Stability, Aggregation Propensity, and Local Flexibility of an IgG1 Monoclonal Antibody
    Majumdar, Ranajoy
    Manikwar, Prakash
    Hickey, John M.
    Samra, Hardeep S.
    Sathish, Hasige A.
    Bishop, Steven M.
    Middaugh, C. Russell
    Volkin, David B.
    Weis, David D.
    BIOCHEMISTRY, 2013, 52 (19) : 3376 - 3389