Precision medicine and oncology: an overview of the opportunities presented by next-generation sequencing and big data and the challenges posed to conventional drug development and regulatory approval pathways

被引：12

作者：

Doherty, M. ^{[1
]}

Metcalfe, T. ^{[2
]}

Guardino, E. ^{[1
]}

Peters, E. ^{[1
]}

Ramage, L. ^{[2
]}

机构：

[1] Genentech Inc, San Francisco, CA 94080 USA

[2] F Hoffmann La Roche, Basel, Switzerland

来源：

ANNALS OF ONCOLOGY | 2016年 / 27卷 / 08期

关键词：

D O I：

10.1093/annonc/mdw165

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Precision medicine approaches make it possible to tailor medical interventions, including combinations, to individual patients at presentation and potentially throughout the course of their disease as new mutations arise and response to treatment diminishes. However, the concept poses challenges to researchers, patients, regulators and payers.

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页码：1644 / 1646

页数：3