Defining antimicrobial resistance in cystic fibrosis

被引：68

作者：

Kidd, Timothy J. ^{[1
]}

Canton, Rafael ^{[2
,3
]}

Ekkelenkamp, Miguel ^{[4
]}

Johansen, Helle Krogh ^{[5
]}

Gilligan, Peter ^{[6
]}

LiPuma, John J. ^{[7
]}

Bell, Scott C. ^{[8
,9
]}

Elborn, J. Stuart ^{[10
,11
,12
]}

Flume, Patrick A. ^{[13
,14
]}

VanDevanter, Donald R. ^{[15
]}

Waters, Valerie J. ^{[16
]}

机构：

[1] Univ Queensland, Lung Bacteria Grp, QIMR Berghofer Med Res Inst, Sch Chem & Mol Biosci, Brisbane, Qld, Australia

[2] Hosp Univ Ramon y Cajal, Serv Microbiol, Madrid, Spain

[3] IRYCIS, Madrid, Spain

[4] Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands

[5] Univ Copenhagen, Rigshosp, Fac Hlth & Med Sci, Dept Clin Microbiol,Dept Clin Med, Copenhagen, Denmark

[6] UNC HealthCare, Clin Microbiol Immunol Labs, Chapel Hill, NC USA

[7] Univ Michigan, Sch Med, Dept Pediat & Communicable Dis, Ann Arbor, MI USA

[8] Prince Charles Hosp, Dept Thorac Med, Brisbane, Qld, Australia

[9] QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia

[10] Imperial Coll, London, England

[11] Royal Brompton Hosp, London, England

[12] Queens Univ Belfast, Belfast, Antrim, North Ireland

[13] Med Univ South Carolina, Dept Med, Charleston, SC USA

[14] Med Univ South Carolina, Dept Pediat, Charleston, SC USA

[15] Case Western Reserve Univ, Sch Med, Dept Pediat, Cleveland, OH 44106 USA

[16] Univ Toronto, Hosp Sick Children, Dept Pediat, Div Infect Dis, Toronto, ON, Canada

来源：

JOURNAL OF CYSTIC FIBROSIS | 2018年 / 17卷 / 06期

关键词：

SMALL-COLONY VARIANTS; PSEUDOMONAS-AERUGINOSA SUSCEPTIBILITY; ANTIBIOTIC SUSCEPTIBILITY; BURKHOLDERIA-CEPACIA; INHALED TOBRAMYCIN; BIOFILM; INFECTIONS; MECHANISMS; GROWTH; EPIDEMIOLOGY;

D O I：

10.1016/j.jcf.2018.08.014

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Antimicrobial resistance (AMR) can present significant challenges in the treatment of cystic fibrosis (CF) lung infections. In CF and other chronic diseases, AMR has a different profile and clinical consequences compared to acute infections and this requires different diagnostic and treatment approaches. This review defines AMR, explains how it occurs, describes the methods used to measure AMR as well as their limitations, and concludes with future directions for research and development in the area of AMR in CF. (C) 2018 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

引用

页码：696 / 704

页数：9

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