miRNA Biogenesis: A Dynamic Pathway

被引：224
|
作者：
Achkar, Natalia P. [1 ]
Cambiagno, Damian A. [1 ]
Manavella, Pablo A. [1 ]
机构：
[1] Univ Nacl Litoral, FBCB, CONICET, Inst Agrobiotecnol Litoral, RA-3000 Santa Fe, Argentina
来源：
TRENDS IN PLANT SCIENCE | 2016年 / 21卷 / 12期
关键词：
DSRNA-BINDING PROTEINS; MICRORNA BIOGENESIS; PRI-MIRNA; SIRNA BIOGENESIS; RNA RECOGNITION; IN-VIVO; ARABIDOPSIS; PLANT; TRANSCRIPTION; COMPLEX;
D O I：
10.1016/j.tplants.2016.09.003
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
MicroRNAs (miRNAs) modulate plant homeostasis through the inactivation of specific mRNAs, especially those encoding transcription factors. A delicate spatial/temporal balance between a miRNA and its targets is central to achieving the appropriate biological outcomes. In this review we discuss our growing understanding of the dynamic regulation of miRNA biogenesis. We put special emphasis on crosstalk between miRNA biogenesis and other cellular processes such as transcription and splicing. We also discuss how the pathway is regulated in specific tissues to achieve harmonious plant development through a subtle balance between gene expression and silencing.
引用
收藏
页码：1034 / 1044
页数：11
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