1-Alkyl-5-((di)alkylamino) Tetrazoles: Building Blocks for Peptide Surrogates

被引：8
|
作者：
Tymtsunik, Andriy V. [1 ,2 ]
Bilenko, Vitaliy A. [2 ]
Kokhan, Serhiy O. [1 ,2 ]
Grygorenko, Oleksandr O. [1 ,2 ]
Volochnyuk, Dmitriy M. [2 ]
Komarov, Igor V. [1 ,2 ]
机构：
[1] Kyiv Natl Taras Shevchenko Univ, UA-01601 Kiev, Ukraine
[2] Enamine Ltd, UA-01103 Kiev, Ukraine
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 02期
关键词：
CIS-AMIDE BOND; ACID; INHIBITORS; CHEMISTRY; DISCOVERY; ANALOGS; ISOSTERES; DESIGN; ANIONS;
D O I：
10.1021/jo2022235
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An approach to the synthesis of 1-alkyl-5-((di)allcylamino)tetrazoles by nucleophilic substitution in 1-alkyl-5-sulfonyl-tetrazoles with anions generated from the primary secondary amines was developed. Tolerance of the method to the presence of some functional groups (i.e., protected amine) in both components of the reaction was demonstrated. Obtained tetrazoles are promising building blocks for the design of peptide surrogates, in particular, for replacement approaches of alkyl urea derivatives.
引用
收藏
页码：1174 / 1180
页数：7
相关论文
共 50 条
12345