Somatostatin receptor positron emission tomography/computed tomography imaging in Merkel cell carcinoma

被引:7
|
作者
Sollini, M. [1 ]
Taralli, S. [2 ]
Milella, M. [3 ]
Erba, P. A. [4 ]
Rubagotti, S. [1 ]
Fraternali, A. [1 ]
Roncali, M. [1 ]
Moscarella, E. [5 ]
Perotti, G. [2 ]
Rufini, V. [2 ]
Versari, A. [1 ]
机构
[1] Arcispedale Santa Maria Nuova IRCCS, Nucl Med Unit, Reggio Emilia, Italy
[2] Univ Cattolica Sacro Cuore, Inst Nucl Med, Rome, Italy
[3] Regina Elena Inst Canc Res, Div Med Oncol, Rome, Italy
[4] Univ Pisa, Reg Ctr Nucl Med, Pisa, Italy
[5] Arcispedale Santa Maria Nuova IRCCS, Skin Canc Unit, Reggio Emilia, Italy
关键词
F-18-FDG; PET/CT;
D O I
10.1111/jdv.13405
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
BackgroundMerkel cell carcinoma (MCC) is an uncommon aggressive primary cutaneous carcinoma with neuroendocrine differentiation. However, literature data about the use of somatostatin receptor positron emission tomography/computed tomography (PET/CT) imaging in MCC are limited and its role is not clearly stated. ObjectiveTo investigate the role of PET/CT using somatostatin analogues radiolabelled with gallium-68 in patients with MCC. MethodsAll patients affected by MCC who performed a somatostatin receptor PET/CT imaging from October 2007 to May 2014 were retrospectively analysed. The diagnostic performances of PET/CT were evaluated on a patient-based analysis and compared to final diagnosis (histology = 3 or clinical/radiological follow-up = 20). ResultsWe evaluated 23 consecutive MCC patients [18 men; median age 71 years (range 47-87)]. Primary tumour was located in ear (1/23), cheek (3/23), arm (2/23), hand (1/23), back (1/23), anal canal (1/23), gluteus (4/23), thigh (3/23) and popliteal fossa (1/23). In 6/23 patients, the site of primary tumour was unknown. PET/CT was performed to detect primary tumour site (4/23) or to stage (8/23) or re-stage (11/23) patients. PET/CT resulted positive in 14/23 patients and according to the final diagnosis was defined true positive, true negative, false positive (FP) and false negative in 11/23, 8/23, 3/23 and 1/23 cases respectively. FP PET/CT results were due to unspecific liver uptake, post-surgical inflammation and pancreatic neuroendocrine tumour. PET/CT was unable to detect primary tumour site in all patients with unknown primary MCC. Sensitivity, specificity and diagnostic accuracy of PET/CT were 92%, 73% and 83% respectively. ConclusionsIn our experience, somatostatin receptor PET/CT imaging resulted useful in patients with MCC and presented high diagnostic performances with a significant impact in disease management although in patients with unknown primary MCC, it was unable to identify the primary tumour site.
引用
收藏
页码:1507 / 1511
页数:5
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