Severe Infantile Axonal Neuropathy with Respiratory Failure Caused by Novel Mutation in X-Linked LAS1L Gene

被引:3
|
作者
Stembalska, Agnieszka [1 ]
Rydzanicz, Malgorzata [2 ]
Walas, Wojciech [3 ]
Gasperowicz, Piotr [2 ]
Pollak, Agnieszka [2 ]
Pienkowski, Victor Murcia [2 ,4 ]
Biela, Mateusz [5 ]
Klaniewska, Magdalena [5 ]
Gamrot, Zuzanna [6 ]
Gronska, Ewa [6 ]
Ploski, Rafal [2 ]
Smigiel, Robert [5 ]
机构
[1] Med Univ, Dept Genet, PL-50368 Wroclaw, Poland
[2] Med Univ Warsaw, Dept Med Genet, PL-02106 Warsaw, Poland
[3] Univ Hosp Opole, Paediat & Neonatal Intens Care Unit, PL-45401 Opole, Poland
[4] Aix Marseille Univ, Marseille Med Genet U1251, MMG, F-13385 Marseille, France
[5] Med Univ, Dept Family & Paediat Nursing, PL-50996 Wroclaw, Poland
[6] Care & Therapy Unit Mechanically Ventilated Child, PL-41506 Chorzow, Poland
关键词
infantile hypotonia; respiratory failure syndrome; SMARD; LAS1L gene; SPINAL MUSCULAR-ATROPHY; VARIANTS; PHENOTYPES;
D O I
10.3390/genes13050725
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
LAS1L encodes a nucleolar ribosomal biogenesis protein and is also a component of the Five Friends of Methylated CHTOP (5FMC) complex. Mutations in the LAS1L gene can be associated with Wilson-Turner syndrome (WTS) and, much more rarely, severe infantile hypotonia with respiratory failure. Here, we present an eighteen-month old boy with a phenotype of spinal muscular atrophy with respiratory distress (SMARD). By applying WES, we identified a novel hemizygous synonymous variant in the LAS1L gene inherited from an unaffected mother (c.846G > C, p.Thr282=). We suggest that the identified variant impairs the RNA splicing process. Furthermore, we proved the absence of any coding regions by qPCR and sequencing cDNA using amplicon deep sequencing and Sanger sequencing methods. According to the SMARD phenotype, severe breathing problems causing respiratory insufficiency, hypotonia, and feeding difficulties were observed in our patient from the first days of life. Remarkably, our case is the second described patient with a SMARD-like phenotype due to a mutation in the LAS1L gene and the first with a variant impacting splicing.
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页数:8
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