Glucocorticoids inhibit the bradykinin B2 receptor increase induced by interleukin-1β in human bronchial smooth muscle cells

被引：15
|
作者：
Schmidlin, F [1 ]
Scherrer, D [1 ]
Landry, Y [1 ]
Gies, JP [1 ]
机构：
[1] Univ Louis Pasteur Strasbourg 1, INSERM, U425, Fac Pharm,Lab Neuroimmunopharmacol, F-67401 Illkirch Graffenstaden, France
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1998年 / 354卷 / 01期
关键词：
asthma; hyperreactivity; glucocorticoid;
D O I：
10.1016/S0014-2999(98)00478-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We studied the effect of the glucocorticoids, dexamethasone and budesonide, on the interleukin-1 beta-induced increase of bradykinin B-2 receptors in cultured human bronchial smooth muscle cells, a cellular model of bronchial hyperreactivity. Both compounds prevented the increase of the bradykinin B-2 mRNA and the bradykinin-induced inositol phosphate accumulation. These results demonstrate a direct effect of glucocorticoids on airway smooth muscle hyperresponsiveness mediated through inhibition of the over-expression of receptors for contractile mediators induced by inflammatory mediators. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：R7 / R8
页数：2
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