Involvement of Autoimmunity in the Pathogenesis of Aggressive Periodontitis

被引：60

作者：

Hendler, A. ^{[1
,3
]}

Mulli, T. K. ^{[4
]}

Hughes, F. J. ^{[4
]}

Perrett, D.

Bombardieri, M. ^{[2
]}

Houri-Haddad, Y. ^{[3
]}

Weiss, E. I. ^{[3
]}

Nissim, A. ^{[1
]}

机构：

[1] Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, Bone & Joint Res Unit, London EC1M 6BQ, England

[2] Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, Ctr Expt Med & Rheumatol, London EC1M 6BQ, England

[3] Hebrew Univ Jerusalem Hadassah Hosp & Med Sch, Fac Med Dent, IL-91120 Jerusalem, Israel

[4] Kings Coll London, Guys Hosp, Inst Dent, London SE1 9RT, England

来源：

JOURNAL OF DENTAL RESEARCH | 2010年 / 89卷 / 12期

关键词：

collagen type I; collagen type III; ROS; periodontitis; COLLAGEN; AUTOANTIBODIES; IMMUNOGLOBULIN; ANTIBODIES; COMPONENTS; GLYCATION; PRODUCTS; DISEASE; SERUM;

D O I：

10.1177/0022034510381903

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n = 18) were tested for the presence of autoantibodies against: (a) native collagen type I (CI) and collagen type III (CIII); (b) CI and CIII post-translationally modified by reactive oxygen species (ROS) of the type present during inflammation; and (c) citrullinated filaggrin-derived peptides (CCP). Autoantibodies to native and ROS-modified CI and CIII as well as autoantibodies to CCP were observed exclusively in patients with AgP and not in those with CP or G. In conclusion, autoimmune reactions to native and post-translationally modified self-antigens may play a role specifically in the pathogenesis of AgP.

引用

页码：1389 / 1394

页数：6

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