Candidate multi-peptide-vaccine against classical swine fever virus induced potent immunity with serological marker

被引：23
|
作者：
Dong, XN [1 ]
Chen, Y [1 ]
Wu, Y [1 ]
Chen, YH [1 ]
机构：
[1] Tsing Hua Univ, Dept Biol, Immunol Lab, Prot Sci Lab MOE, Beijing 100084, Peoples R China
来源：
VACCINE | 2005年 / 23卷 / 28期
关键词：
classical swine fever virus (CSFV); multi-peptide-vaccine (MPV); marker vaccines; aluminum adjuvant;
D O I：
10.1016/j.vaccine.2005.02.008
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Our previous study proposed a protective multi-peptide-vaccine (MPV) with Freund's adjuvant against classical swine fever virus (CSFV). In this study, another candidate MPV, using aluminum adjuvant, was further examined. All immunized pigs kept healthy during the experimental period, while the control group rapidly showed clinical symptoms and died. Moreover. anti-sera from MPV-immunized pigs could interact with peptides involved in the MPV. in contrast to anti-sera from non-immunized or infected ones, This property permits MPV-immunized pigs to be easily differentiated from infected ones with simple serological method. Therefore, this new MPV is suitable to act as a candidate marker vaccine against CSFV. © 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3630 / 3633
页数：4
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