Rethinking Greulich and Pyle: A Deep Learning Approach to Pediatric Bone Age Assessment Using Pediatric Trauma Hand Radiographs

Purpose: To develop a deep learning approach to bone age assessment based on a training set of developmentally normal pediatric hand radiographs and to compare this approach with automated and manual bone age assessment methods based on Greulich and Pyle (GP). Methods: In this retrospective study, a convolutional neural network (trauma hand radiograph-trained deep learning bone age assessment method [TDL-BAAM]) was trained on 15 129 frontal view pediatric trauma hand radiographs obtained between December 14, 2009, and May 31, 2017, from Children's Hospital of New York, to predict chronological age. A total of 214 trauma hand radiographs from Hasbro Children's Hospital were used as an independent test set. The test set was rated by the TDL-BAAM model as well as a GP-based deep learning model (GPDL-BAAM) and two pediatric radiologists (radiologists 1 and 2) using the GP method. All ratings were compared with chronological age using mean absolute error (MAE), and standard concordance analyses were performed. Results: The MAE of the TDL-BAAM model was 11.1 months, compared with 12.9 months for GPDL-BAAM (P=.0005), 14.6 months for radiologist 1 (P<.0001), and 16.0 for radiologist 2 (P<.0001). For TDL-BAAM, 95.3% of predictions were within 24 months of chronological age compared with 91.6% for GPDL-BAAM (P=.096), 86.0% for radiologist 1 (P<.0001), and 84.6% for radiologist 2 (P<.0001). Concordance was high between all methods and chronological age (intraclass coefficient > 0.93). Deep learning models demonstrated a systematic bias with a tendency to overpredict age for younger children versus radiologists who showed a consistent mean bias. Conclusion: A deep learning model trained on pediatric trauma hand radiographs is on par with automated and manual GP-based methods for bone age assessment and provides a foundation for developing population-specific deep learning algorithms for bone age assessment in modern pediatric populations. (C) RSNA, 2020