Micro-RNAs and breast cancer

被引：99
|
作者：
Le Quesne, John [1 ]
Caldas, Carlos [1 ]
机构：
[1] Canc Res UK, Cambridge Res Inst, Li Ka Shing Ctr, Cambridge CB2 0RE, England
来源：
MOLECULAR ONCOLOGY | 2010年 / 4卷 / 03期
关键词：
Micro-RNA; Breast cancer; oncogenes; Tumor suppressors; ESTROGEN-RECEPTOR-ALPHA; TUMOR-SUPPRESSOR GENE; CELL-GROWTH; MICRORNA-21; TARGETS; DOWN-REGULATION; MESSENGER-RNAS; LET-7; MICRORNA; MIR-200; FAMILY; TAMOXIFEN RESISTANCE; EXPRESSION;
D O I：
10.1016/j.molonc.2010.04.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Micro-RNAs (miRs) are a recently described class of genes, encoding small non-coding RNA molecules, which primarily act by down-regulating the translation of target mRNAs. miRs are involved in a range of normal physiological processes, notably differentiation and cell type determination. It has become apparent that they are also key factors in cancer, playing both oncogenic and tumour-suppressing roles. We discuss here what is known of miR biology in the normal breast, and of their emerging roles in breast cancer. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：230 / 241
页数：12
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