Successful management of an arteriovenous malformation with trametinib in a patient with capillary-malformation arteriovenous malformation syndrome and cardiac compromise

被引：34

作者：

Nicholson, Cynthia L. ^{[1
]}

Flanagan, Siobhan ^{[2
]}

Murati, Michael ^{[2
]}

Boull, Christina ^{[1
]}

McGough, Erin ^{[3
]}

Ameduri, Rebecca ^{[4
]}

Weigel, Brenda ^{[3
]}

Maguiness, Sheilagh ^{[1
]}

机构：

[1] Univ Minnesota, Dept Dermatol, 2450 Riverside Ave, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Pediat Radiol, Minneapolis, MN USA

[3] Univ Minnesota, Dept Pediat Hematol Oncol, Minneapolis, MN USA

[4] Univ Minnesota, Dept Pediat Cardiol, Minneapolis, MN USA

来源：

PEDIATRIC DERMATOLOGY | 2022年 / 39卷 / 02期

关键词：

MEK inhibitor; skin signs of systemic disease; therapy-systemic; trametinib; vascular malformation;

D O I：

10.1111/pde.14912

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Capillary malformation-arteriovenous malformation (CM-AVM) syndrome is an autosomal dominant condition characterized by multifocal, noncontiguous pink patches on the skin that often have a surrounding pale halo. In some cases, an association with a fast flow, arteriovenous malformation (AVM) can be identified. Here, we describe a case report of a 16-year-old woman with CM-AVM syndrome and significant cardiac compromise successfully treated with trametinib, a mitogen-activated protein kinase (MEK) inhibitor.

引用

页码：316 / 319

页数：4

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