Wnt Signaling Pathways: A Role in Pain Processing

被引：23
|
作者：
Tang, Yiting [1 ,2 ]
Chen, Yupeng [1 ,2 ]
Liu, Rui [3 ]
Li, Weidong [3 ]
Hua, Baojin [3 ]
Bao, Yanju [3 ]
机构：
[1] China Acad Chinese Med Sci, Guanganmen Hosp, Beixiange 5, Beijing 100053, Peoples R China
[2] Beijing Univ Chinese Med, Beijing North Third Ring Rd 11, Beijing 100029, Peoples R China
[3] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Oncol, Beixiange 5, Beijing 100053, Peoples R China
来源：
NEUROMOLECULAR MEDICINE | 2022年 / 24卷 / 03期
基金：
中国国家自然科学基金;
关键词：
WNT signaling; Pain processing; Neuropathic pain; Cancer pain; Diabetic neuralgia; PERIPHERAL NEUROPATHIC PAIN; ROOT GANGLION NEURONS; PLANAR CELL POLARITY; BETA-CATENIN; NEUROTROPHIC FACTOR; EPITHELIAL-CELLS; DENDRITIC CELLS; NERVE INJURY; EXPRESSION; BRAIN;
D O I：
10.1007/s12017-021-08700-z
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The wingless-related integration site (Wnt) signaling pathway plays an essential role in embryonic development and nervous system regulation. It is critically involved in multiple types of neuropathic pain (NP), such as HIV-related NP, cancer pain, diabetic neuralgia, multiple sclerosis-related NP, endometriosis pain, and other painful diseases. Wnt signaling is also implicated in the pain induced by sciatic nerve compression injury and selective spinal nerve ligation. Thus, the Wnt signaling pathway may be a potential therapeutic target for NP.
引用
收藏
页码：233 / 249
页数：17
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