Treatment of wild-type gastrointestinal stromal tumor (WT-GIST) with imatinib and sunitinib

被引：10

作者：

Murray, Matthew ^{[1
]}

Hatcher, Helen ^{[1
,4
]}

Jessop, Flora ^{[2
]}

Williams, Denise ^{[1
]}

Carroll, Nicholas ^{[3
]}

Bulusu, Ramesh ^{[1
]}

Judson, Ian ^{[4
]}

机构：

[1] Addenbrookes Hosp, Dept Oncol, Cambridge, England

[2] Addenbrookes Hosp, Dept Histopathol, Cambridge, England

[3] Addenbrookes Hosp, Dept Radiol, Cambridge, England

[4] Royal Marsden Hosp, Sarcoma Unit, London SW3 6JJ, England

来源：

PEDIATRIC BLOOD & CANCER | 2008年 / 50卷 / 02期

关键词：

gastrointestinal stromal tumors; imatinib; sunitinib; KIT; PDGFRA; pediatric;

D O I：

10.1002/pbc.21312

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a rare case of advanced, metastatic gastrointestinal stromal tumor (GIST) in a young female. Molecular analysis of the tumor revealed wild-type (WT) KIT and platelet derived growth factor receptor alpha (PDGFRA) gene status with no mutations characteristic of adult GIST. Despite this she had clinical benefit and evidence of radiological response to sequential treatment with the tyrosine kinase inhibitors imatinib and sunitinib. Pediatr Blood Cancer 2008;50:386-388. (c) 2007 Wiley-Liss, Inc.

引用

页码：386 / 388

页数：3

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