Bacillus spores for vaccine delivery

被引：47
|
作者：
Oggioni, MR [1 ]
Ciabattini, A [1 ]
Cuppone, AM [1 ]
Pozzi, G [1 ]
机构：
[1] Univ Siena, Dipartimento Biol Mol, Policlin Le Scotte IS, Lab Microbiol Mol & Biotecnol, I-53100 Siena, Italy
来源：
VACCINE | 2003年 / 21卷
关键词：
Bacillus subtilis; Bacillus anthracis; recombinant vaccine;
D O I：
10.1016/S0264-410X(03)00207-X
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Spores of the genus Bacillus have been used for a long time as probiotics for oral bacteriotherapy both in humans and in animals. Spores are also employed in a veterinary vaccine against anthrax. Despite this long lasting and extensive use, the specific contribution of spores to the beneficial effects of probiotics and to the immunogenicity of the vaccine is not completely elucidated. This review focuses on the different aspects of the use of spore preparations. In particular the use of recombinant spores as vaccine delivery vehicles is described and discussed. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：S96 / S101
页数：6
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