The Pioneer Round of Translation: Features and Functions

被引：167
|
作者：
Maquat, Lynne E. [1 ,2 ]
Tarn, Woan-Yuh [1 ,2 ,4 ]
Isken, Olaf [3 ]
机构：
[1] Univ Rochester, Sch Med & Dent, Dept Biochem & Biophys, Rochester, NY 14642 USA
[2] Univ Rochester, Sch Med & Dent, Ctr RNA Biol, Rochester, NY 14642 USA
[3] Univ Lubeck, Inst Virol & Cell Biol, D-23562 Lubeck, Germany
[4] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan
来源：
CELL | 2010年 / 142卷 / 03期
关键词：
MESSENGER-RNA DECAY; EXON-JUNCTION COMPLEX; UPF1; PHOSPHORYLATION; ENHANCE TRANSLATION; PROLONGED HYPOXIA; GENE-EXPRESSION; BINDING-PROTEIN; NONSENSE; MECHANISMS; INITIATION;
D O I：
10.1016/j.cell.2010.07.022
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during and after the pioneer round, steady-state cycles of mRNA translation generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of signaling pathways that are particular to newly synthesized mRNAs regulate critical functions of the pioneer round.
引用
收藏
页码：368 / 374
页数：7
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