A biochemical translinear principle with weak inversion ISFETs

被引：39

作者：

Shepherd, LM ^{[1
]}

Toumazou, C

机构：

[1] Univ London Imperial Coll Sci & Technol, Dept Elect & Elect Engn, London SW7 2BT, England

[2] Univ London Imperial Coll Sci & Technol, Inst Biomed Engn, London SW7 2BT, England

来源：

IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS | 2005年 / 52卷 / 12期

关键词：

chemically sensitive ion-sensitive field effect transistor (ChemFET); CMOS; ISFET; low power; pH; weak inversion;

D O I：

10.1109/TCSI.2005.857919

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

A weak inversion region is shown to exist in ion-sensitive field effect transistor (ISFET) sensors. It is therefore proposed that the ISFET and its chemically sensitive (ChemFET) counterparts be used as translinear elements in the synthesis of novel biochemical input stages which perform real-time mathematical manipulation of biochemical signals. A Biochemical Translinear Principle using weakly inverted ChemFETs is presented. A low-power current-mode input stage circuit is presented as an application of the principle. This yields a linear relation between drain current and hydrogen ion concentration valid over four decades. This paper demonstrates an important and necessary step toward biochemical VLSI.

引用

页码：2614 / 2619

页数：6

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