An efficient synthesis of a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 via asymmetric dianionic cyanomethylation of N-Boc-L-(+)-glutamic acid dimethyl ester

被引：47

作者：

Tian, QP ^{[1
]}

Nayyar, NK ^{[1
]}

Babu, S ^{[1
]}

Chen, LJ ^{[1
]}

Tao, JH ^{[1
]}

Lee, S ^{[1
]}

Tibbetts, A ^{[1
]}

Moran, T ^{[1
]}

Liou, J ^{[1
]}

Guo, M ^{[1
]}

Kennedy, TP ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, La Jolla Labs, Chem Res & Dev, San Diego, CA 92121 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 39期

关键词：

asymmetric synthesis; lactams; alkylation;

D O I：

10.1016/S0040-4039(01)01416-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthetic route to a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 has been developed employing a key asymmetric dianionic cyanomethylation of N-Boc-L-(+)-glutamic acid dimethyl ester. This methodology enables the preparation of this compound in kilogram quantities with an overall yield of 30%. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6807 / 6809

页数：3