Chemical Constituents from the Aerial Parts of Isodon coetsa and their Cytotoxicity

被引：11

作者：

Zhao, Wei ^{[1
,2
]}

Pu, Jian Xin ^{[1
]}

Du, Xue ^{[1
]}

Wu, Ying Li ^{[3
,4
]}

Zhao, Yong ^{[1
]}

He, Fei ^{[1
]}

Zhang, Hai Bo ^{[1
]}

Xue, Yong Bo ^{[1
,2
]}

Xiao, Wei Lie ^{[1
]}

Chen, Guo Qiang ^{[3
,4
]}

Sun, Han Dong ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[3] Shanghai JiaoTong Univ Sch Med SJTU SM Coll, Chinese Minist Educ, Dept Pathophysiol, Shanghai 200025, Peoples R China

[4] Shanghai JiaoTong Univ Sch Med SJTU SM Coll, Chinese Minist Educ, Key Lab Cell Differentiat & Apoptosis, Shanghai 200025, Peoples R China

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2011年 / 34卷 / 12期

关键词：

Neolignan; Triterpenoid; Diterpenoid; Isodon coetsa; Cytotoxicity; Human tumor cell lines; ENT-KAURANOIDS; DITERPENOID CONSTITUENTS; RABDOSIA-COETSA; A-C; XEROPHILUS; RUBESCENS; NERVOSUS;

D O I：

10.1007/s12272-011-1201-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new compounds (1-3), including a neolignan, a triterpenoid, and a diterpenoid, together with twenty known compounds (4-23), were isolated from the aerial parts of Isodon coetsa. Their structures and relative configurations were elucidated on the basis of spectroscopic data. Compounds 1, 3, 5-9, 11-13, 16-17, and 19-23 were evaluated for their cytotoxicity against HT-29, BEL-7402, and SK-OV-3 human tumor cell lines. Compound 7 showed significant inhibitory effects on all three types of cells, with IC(50) values of 2.52, 3.06, 2.14 mu M, respectively.

引用

页码：2007 / 2014

页数：8

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