Follow up study of endogenous insulin secretion in GAD-Ab (+) NIDDM. Report of West Japan (Kyushu, Yamaguchi, Osaka) study for GAD-Ab (+) diabetes

被引：0

作者：

Sera, Y ^{[1
]}

Takino, H ^{[1
]}

Yamasaki, H ^{[1
]}

Abe, T ^{[1
]}

Fujita, N ^{[1
]}

Degawa, M ^{[1
]}

Ozaki, M ^{[1
]}

Yamakawa, K ^{[1
]}

Uotani, S ^{[1
]}

Kawasaki, E ^{[1
]}

Yamaguchi, Y ^{[1
]}

Eguchi, K ^{[1
]}

Kanazawa, Y ^{[1
]}

Nagataki, S ^{[1
]}

机构：

[1] Nagasaki Univ, Sch Med, Dept Internal Med 1, Nagasaki 8528501, Japan

来源：

DIABETES MELLITUS: RECENT ADVANCES FOR THE 21ST CENTURY | 2000年 / 1209卷

关键词：

Japanese; 75g-OGTT; CPR; autoimmunity;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A longitudinal study of GAD-Ab (+) NIDDMs from diagnosis to insulin-dependency is underway in Japan since 1996. A total of 2,658 Japanese NIDDMs treated by OHA and / or diet were randomly selected from 15 centers between 1996 and 1998. We detected the GAD-Ab in 54 (2.0%) patients. We have followed the endogenous insulin secretion at 75g OGTT in 10 out of 54 GAD-Ab (+) patients. Decreased insulin secretion during the follow up period was observed in 7 patients and no change in 3. We compared the clinical characteristics between these groups at registry. No significant difference, such as BMI, HbA1c at the registry and duration of diabetes, was observed except for GAD-Ab titer (160 +/- 108 vs. 32 +/- 28 U I ml, p <0.05). There was no significant correlation between GAD-Ab titer and Delta CPR during the follow up period. These results indicated that the endogenous insulin secretion in GAD-Ab (+) NIDDM decreased in short period and the high titer of GAD-Ab detected in NIDDMs would be an early marker for insulin dependent state.

引用

页码：103 / 107

页数：5

共 6 条

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Takino, H
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DIABETIC MEDICINE, 2002, 19 (09) : 730 - 734
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NEUROLOGY, 1997, 48 (03) : 56003 - 56003
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Takino, H
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DIABETES, 1999, 48 : A87 - A87
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Sasaki, A
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DIABETES RESEARCH AND CLINICAL PRACTICE, 1996, 34 (01) : 47 - 55
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Sasaki, A
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DIABETES RESEARCH AND CLINICAL PRACTICE, 1997, 36 (01) : 41 - 47
[6] GAD65 vaccination significantly reduces insulin dependence at five years follow-up in a dose escalating study in adult-onset autoimmune diabetes patients
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DIABETOLOGIA, 2008, 51 : S230 - S230

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