Hepatocyte Gdf15 Is Sufficient for Increased Plasma GDF15 Levels and Body Weight Constraint during High-Fat-Diet Feeding and Restores Insulin Sensitivity in a Liver-Specific Manner

被引：0
|
作者：
Xie, Bingxian
Murali, Anjana
Vandevender, Amber
Silva, Agustin A. Gil
Bello, Fiona
Sipula, Ian J.
Dedousis, Nikolaos
Alder, Jonathan
Jurczak, Michael J.
机构：
来源：
DIABETES | 2022年 / 71卷
关键词：
D O I：
10.2337/db22-3-OR
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
3-OR
引用
收藏
页数：1
相关论文
共 4 条
  • [1] Insulin Sensitivity Is Impaired Independent of Changes in Body Weight in Liver-Specific GDF15 Knockout Mice
    Kastroll, Jake
    Jurczak, Michael J.
    Alder, Jonathan
    Vandevender, Amber
    Dedousis, Nikolaos
    Sipula, Ian J.
    DIABETES, 2024, 73
  • [2] Hepatocyte-derived GDF15 suppresses feeding and improves insulin sensitivity in obese mice
    Xie, Bingxian
    Murali, Anjana
    Vandevender, Amber M.
    Chen, Jeffrey
    Silva, Agustin Gil
    Bello, Fiona M.
    Chuan, Byron
    Bahudhanapati, Harinath
    Sipula, Ian
    Dedousis, Nikolaos
    Shah, Faraaz A.
    O'Donnell, Christopher P.
    Alder, Jonathan K.
    Jurczak, Michael J.
    ISCIENCE, 2022, 25 (12)
  • [3] Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice
    Patel, Satish
    Haider, Afreen
    Alvarez-Guaita, Anna
    Bidault, Guillaume
    Moustafa, Julia Sarah El-Sayed
    Guiu-Jurado, Esther
    Tadross, John A.
    Warner, James
    Harrison, James
    Virtue, Samuel
    Scurria, Fabio
    Zvetkova, Ilona
    Bluher, Matthias
    Small, Kerrin S.
    O'Rahilly, Stephen
    Savage, David B.
    MOLECULAR METABOLISM, 2022, 65
  • [4] Hepatocyte-specific GDF15 overexpression improves high-fat diet-induced obesity and hepatic steatosis in mice via hepatic FGF21 induction
    Takeuchi, Kento
    Yamaguchi, Kanji
    Takahashi, Yusuke
    Yano, Kota
    Okishio, Shinya
    Ishiba, Hiroshi
    Tochiki, Nozomi
    Kataoka, Seita
    Fujii, Hideki
    Iwai, Naoto
    Seko, Yuya
    Umemura, Atsushi
    Moriguchi, Michihisa
    Okanoue, Takeshi
    Itoh, Yoshito
    SCIENTIFIC REPORTS, 2024, 14 (01):
1