Plasmodium falciparum genetic crosses in a humanized mouse model

被引：0
|
作者：
Vaughan, Ashley M. [1 ]
Pinapati, Richard S. [2 ]
Cheeseman, Ian H. [3 ]
Camargo, Nelly [1 ]
Fishbaugher, Matthew [1 ]
Checkley, Lisa A. [2 ]
Nair, Shalini [3 ]
Hutyra, Carolyn A. [2 ]
Nosten, Francois H. [4 ]
Anderson, Timothy J. C. [3 ]
Ferdig, Michael T. [2 ]
Kappe, Stefan H. I. [1 ,5 ]
机构：
[1] Ctr Infect Dis Res, Seattle, WA 98109 USA
[2] Univ Notre Dame, Dept Biol Sci, Eck Inst Global Hlth, Notre Dame, IN 46556 USA
[3] Texas Biomed Res Inst, San Antonio, TX USA
[4] Mahidol Univ, Shoklo Malaria Res Unit, Mahidol Oxford Trop Med Res Unit, Mae Sot, Thailand
[5] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA
来源：
NATURE METHODS | 2015年 / 12卷 / 07期
关键词：
ARTEMISININ RESISTANCE; CONTINUOUS-CULTURE; MALARIA PARASITES; PATHWAYS; PATTERNS; STRAIN; CYCLE; MICE;
D O I：
10.1038/NMETH.3432
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Genetic crosses of phenotypically distinct strains of the human malaria parasite Plasmodium falciparum are a powerful tool for identifying genes controlling drug resistance and other key phenotypes. Previous studies relied on the isolation of recombinant parasites from splenectomized chimpanzees, a research avenue that is no longer available. Here we demonstrate that human-liver chimeric mice support recovery of recombinant progeny for the identification of genetic determinants of parasite traits and adaptations.
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收藏
页码：631 / +
页数：6
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