Genetic Polymorphisms and head and neck cancer outcomes: A review

被引：49

作者：

Hopkins, Jessica ^{[1
,2
,3
,4
]}

Cescon, David W. ^{[1
,2
,5
]}

Tse, Darren ^{[1
,2
]}

Bradbury, Penelope ^{[1
,2
]}

Xu, Wei ^{[6
]}

Ma, Clement ^{[6
]}

Wheatley-Price, Paul ^{[1
]}

Waldron, John ^{[7
]}

Goldstein, David ^{[8
]}

Meyer, Francois ^{[9
]}

Bairati, Isabelle ^{[9
]}

Liu, Geoffrey ^{[1
,2
,10
,11
]}

机构：

[1] Princess Margaret Hosp, Dept Med, Div Hematol & Med Oncol, Toronto, ON M5G 2M9, Canada

[2] Ontario Canc Inst, Dept Med Biophys, Div Appl Mol Oncol, Toronto, ON M4X 1K9, Canada

[3] McMaster Univ, Community Med Residency Program, Hamilton, ON, Canada

[4] McMaster Univ, Dept Family Med, Hamilton, ON L8S 4L8, Canada

[5] Princess Margaret Hosp, Dept Med, Div Gen Internal Med, Toronto, ON M4X 1K9, Canada

[6] Princess Margaret Hosp, Biostat Unit, Toronto, ON M4X 1K9, Canada

[7] Princess Margaret Hosp, Dept Radiat Oncol, Toronto, ON M4X 1K9, Canada

[8] Univ Toronto, Dept Otolaryngol, Univ Hlth Network, Toronto, ON M5S 1A1, Canada

[9] Univ Laval, Ctr Rech Cancerol, Quebec City, PQ, Canada

[10] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Med, Boston, MA USA

[11] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2008年 / 17卷 / 03期

关键词：

D O I：

10.1158/1055-9965.EPI-07-2714

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Head and neck cancer (HNC) patients have variable prognoses even within the same clinical stage and while receiving similar treatments. The number of studies of genetic polymorphisms as prognostic factors of HNC outcomes is growing. Candidate polymorphisms have been evaluated in DNA repair, cell cycle, xenobiotic metabolism, and growth factor pathways. Polymorphisms of XRCC1, FGFR, and CCND1 have been consistently associated with HNC survival in at least two studies, whereas most of the other polymorphisms have either conflicting data or were from single studies. Heterogeneity and lack of description of patient populations and lack of accounting for multiple comparisons were common problems in a significant proportion of studies. Despite a large number of exploratory studies, large replication studies in well-characterized HNC populations are warranted.

引用

页码：490 / 499

页数：10

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