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- [1] PHARMACOGENOMICS REVEALS SYNERGISTIC INHIBITION OF ERBB2 AND PI3K SIGNALING AS A THERAPEUTIC STRATEGY FOR EPENDYMOMANEURO-ONCOLOGY, 2020, 22 : 314 - 314Pauck, David论文数: 0 引用数: 0 h-index: 0机构: German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, Germany German Canc Res Ctr, Partner Site Essen Dusseldorf, Dusseldorf, Germany Heinrich Heine Univ Dusseldorf, Fac Med, Dept Pediat Oncol Hematol & Clin Immunol, Dusseldorf, Germany German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, Germany论文数: 引用数: h-index:机构:Cascao, Rita论文数: 0 引用数: 0 h-index: 0机构: Univ Lisbon, Fac Med, Inst Mol Med, Lisbon, Portugal German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, GermanySarikaya-Seiwert, Sevgi论文数: 0 引用数: 0 h-index: 0机构: Univ Bonn, Med Ctr, Dept Neurosurg, Bonn, Germany Heinrich Heine Univ Dusseldorf, Fac Med, Dept Neurosurg, Dusseldorf, Germany German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, GermanyMarquardt, Viktoria论文数: 0 引用数: 0 h-index: 0机构: German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, Germany German Canc Res Ctr, Partner Site Essen Dusseldorf, Dusseldorf, Germany Heinrich Heine Univ Dusseldorf, Inst Pharmaceut & Med Chem, Dusseldorf, Germany German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, GermanyPicard, Daniel论文数: 0 引用数: 0 h-index: 0机构: German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, Germany German Canc Res Ctr, Partner Site Essen Dusseldorf, Dusseldorf, Germany Heinrich Heine Univ Dusseldorf, Fac Med, Dept Pediat Oncol Hematol & Clin Immunol, Dusseldorf, Germany German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, GermanyBartl, Jasmin论文数: 0 引用数: 0 h-index: 0机构: German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, Germany German Canc Res Ctr, Partner Site Essen Dusseldorf, Dusseldorf, Germany Heinrich Heine Univ Dusseldorf, Fac Med, Dept Pediat Oncol Hematol & Clin Immunol, Dusseldorf, Germany German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, GermanyBluemel, Lena论文数: 0 引用数: 0 h-index: 0机构: German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, Germany German Canc Res Ctr, Partner Site Essen Dusseldorf, Dusseldorf, Germany Heinrich Heine Univ Dusseldorf, Fac Med, Dept Pediat Oncol Hematol & Clin Immunol, Dusseldorf, Germany German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, GermanyMaue, Mara论文数: 0 引用数: 0 h-index: 0机构: German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, Germany German Canc Res Ctr, Partner Site Essen Dusseldorf, Dusseldorf, Germany Heinrich Heine Univ Dusseldorf, Fac Med, Dept Pediat Oncol Hematol & Clin Immunol, Dusseldorf, Germany German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, GermanyDimitriadis, Christian论文数: 0 引用数: 0 h-index: 0机构: German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, Germany German Canc Res Ctr, Partner Site Essen Dusseldorf, Dusseldorf, Germany Heinrich Heine Univ Dusseldorf, Fac Med, Dept Pediat Oncol Hematol & Clin Immunol, Dusseldorf, Germany German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, GermanyTaban, Kuebra论文数: 0 引用数: 0 h-index: 0机构: German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, Germany German Canc Res Ctr, Partner Site Essen Dusseldorf, Dusseldorf, Germany Heinrich Heine Univ Dusseldorf, Fac Med, Dept Pediat Oncol Hematol & Clin Immunol, Dusseldorf, Germany German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, GermanyFischer, Ute论文数: 0 引用数: 0 h-index: 0机构: Heinrich Heine Univ Dusseldorf, Fac Med, Dept Pediat Oncol Hematol & Clin Immunol, Dusseldorf, Germany German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, GermanySteiger, Hans Jakob论文数: 0 引用数: 0 h-index: 0机构: Heinrich Heine Univ Dusseldorf, Fac Med, Dept Neurosurg, Dusseldorf, Germany German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, GermanyFaria, Claudia论文数: 0 引用数: 0 h-index: 0机构: Univ Lisbon, Fac Med, Inst Mol Med, Lisbon, Portugal Ctr Hosp Univ Lisboa Norte, Hosp Santa Maria, Dept Neurosurg, Lisbon, Portugal German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, Germany论文数: 引用数: h-index:机构:Borkhardt, Arndt论文数: 0 引用数: 0 h-index: 0机构: Heinrich Heine Univ Dusseldorf, Fac Med, Dept Pediat Oncol Hematol & Clin Immunol, Dusseldorf, Germany German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, GermanyBeez, Thomas论文数: 0 引用数: 0 h-index: 0机构: Heinrich Heine Univ Dusseldorf, Fac Med, Dept Neurosurg, Dusseldorf, Germany German Canc Consortium, Div Pediat Neurooncogen, Dusseldorf, Germany论文数: 引用数: h-index:机构:
- [2] PI3K Inhibition Overcomes Trastuzumab Resistance: Blockade of ErbB2/ErbB3 Is Not Always EnoughCANCER CELL, 2009, 15 (05) : 353 - 355Hynes, Nancy E.论文数: 0 引用数: 0 h-index: 0机构: Friedrich Miescher Inst Biomed Res, CH-4059 Basel, Switzerland Friedrich Miescher Inst Biomed Res, CH-4059 Basel, SwitzerlandDey, Julien H.论文数: 0 引用数: 0 h-index: 0机构: Friedrich Miescher Inst Biomed Res, CH-4059 Basel, Switzerland Friedrich Miescher Inst Biomed Res, CH-4059 Basel, Switzerland
- [3] MEK Inhibition Leads to PI3K/AKT Activation by Relieving a Negative Feedback on ERBB ReceptorsCANCER RESEARCH, 2012, 72 (13) : 3228 - 3237Turke, Alexa B.论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02129 USA Harvard Univ, Sch Med, Dept Med, Boston, MA USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02129 USASong, Youngchul论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02129 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02129 USACosta, Carlotta论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02129 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02129 USACook, Rebecca论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Ingram Canc Ctr, Nashville, TN USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02129 USAArteaga, Carlos L.论文数: 0 引用数: 0 h-index: 0机构: Vanderbilt Ingram Canc Ctr, Nashville, TN USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02129 USAAsara, John M.论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Sch Med, Dept Med, Boston, MA USA Beth Israel Deaconess Med Ctr, Div Signal Transduct, Boston, MA 02215 USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02129 USAEngelman, Jeffrey A.论文数: 0 引用数: 0 h-index: 0机构: Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02129 USA Harvard Univ, Sch Med, Dept Med, Boston, MA USA Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02129 USA
- [4] KIF11 promotes cell proliferation via ERBB2/PI3K/AKT signaling pathway in gallbladder cancerINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2021, 17 (02): : 514 - 526Dang Wei论文数: 0 引用数: 0 h-index: 0机构: Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gen Surg, Sch Med, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Lab Gen Surg, Sch Med, Shanghai 200092, Peoples R China Shanghai Key Lab Biliary Tract Dis Res, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes, Shanghai 200127, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gen Surg, Sch Med, Shanghai 200092, Peoples R ChinaBian Rui论文数: 0 引用数: 0 h-index: 0机构: Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Biliary Pancreat Surg, 160 Pujian Rd, Shanghai 200127, Peoples R China Shanghai Key Lab Biliary Tract Dis Res, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes, Shanghai 200127, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gen Surg, Sch Med, Shanghai 200092, Peoples R ChinaFan Qingquan论文数: 0 引用数: 0 h-index: 0机构: Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gen Surg, Sch Med, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Lab Gen Surg, Sch Med, Shanghai 200092, Peoples R China Shanghai Key Lab Biliary Tract Dis Res, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes, Shanghai 200127, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gen Surg, Sch Med, Shanghai 200092, Peoples R ChinaCai Chen论文数: 0 引用数: 0 h-index: 0机构: Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gen Surg, Sch Med, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Lab Gen Surg, Sch Med, Shanghai 200092, Peoples R China Shanghai Key Lab Biliary Tract Dis Res, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes, Shanghai 200127, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gen Surg, Sch Med, Shanghai 200092, Peoples R ChinaHu Yun Ping论文数: 0 引用数: 0 h-index: 0机构: Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gen Surg, Sch Med, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Lab Gen Surg, Sch Med, Shanghai 200092, Peoples R China Shanghai Key Lab Biliary Tract Dis Res, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes, Shanghai 200127, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gen Surg, Sch Med, Shanghai 200092, Peoples R ChinaSong Xiaoling论文数: 0 引用数: 0 h-index: 0机构: Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gen Surg, Sch Med, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Lab Gen Surg, Sch Med, Shanghai 200092, Peoples R China Shanghai Key Lab Biliary Tract Dis Res, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes, Shanghai 200127, Peoples R China Harbin Med Univ, Key Lab Hepatosplen Surg, Minist Educ, Harbin, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gen Surg, Sch Med, Shanghai 200092, Peoples R ChinaWeng Hao论文数: 0 引用数: 0 h-index: 0机构: Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gen Surg, Sch Med, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Lab Gen Surg, Sch Med, Shanghai 200092, Peoples R China Shanghai Key Lab Biliary Tract Dis Res, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes, Shanghai 200127, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gen Surg, Sch Med, Shanghai 200092, Peoples R ChinaGu Jun论文数: 0 引用数: 0 h-index: 0机构: Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gen Surg, Sch Med, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Lab Gen Surg, Sch Med, Shanghai 200092, Peoples R China Shanghai Key Lab Biliary Tract Dis Res, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes, Shanghai 200127, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Gen Surg, Sch Med, Shanghai 200092, Peoples R China
- [5] Inhibition of PI3K/Akt/mTOR Signaling by Natural ProductsANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2013, 13 (07) : 967 - 970Huang, Shile论文数: 0 引用数: 0 h-index: 0机构: Louisiana State Univ, Dept Biochem & Mol Biol, Hlth Sci Ctr, Shreveport, LA 71130 USA Louisiana State Univ, Feist Weiller Canc Ctr, Hlth Sci Ctr, Shreveport, LA 71130 USA Louisiana State Univ, Dept Biochem & Mol Biol, Hlth Sci Ctr, Shreveport, LA 71130 USA
- [6] Inhibition of tumor cell invasion and ErbB2/PI3K signaling pathways by the glutathione disulfide -mimetic NOV-002CANCER RESEARCH, 2009, 69Gumireddy, Kiranmai论文数: 0 引用数: 0 h-index: 0机构: Wistar Inst Anat & Biol, Philadelphia, PA 19104 USAPazoles, Christopher论文数: 0 引用数: 0 h-index: 0机构: Wistar Inst Anat & Biol, Philadelphia, PA 19104 USAVulfson, Evgeny论文数: 0 引用数: 0 h-index: 0机构: Wistar Inst Anat & Biol, Philadelphia, PA 19104 USAHuang, Qihong论文数: 0 引用数: 0 h-index: 0机构: Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA
- [7] Role of SMO in the Activation of PI3K/AKT Signaling in DLBCLMODERN PATHOLOGY, 2017, 30 : 382A - 382AVaghefi, Amineh论文数: 0 引用数: 0 h-index: 0机构: Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USAAgarwal, Nitin K.论文数: 0 引用数: 0 h-index: 0机构: Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USAKunkalla, Kranthi论文数: 0 引用数: 0 h-index: 0机构: Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USAKim, Chae Hwa论文数: 0 引用数: 0 h-index: 0机构: Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USATjendra, Youley论文数: 0 引用数: 0 h-index: 0机构: Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USALandgraf, Ralf论文数: 0 引用数: 0 h-index: 0机构: Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USAVega, Francisco论文数: 0 引用数: 0 h-index: 0机构: Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA
- [8] Role of SMO in the Activation of PI3K/AKT Signaling in DLBCLLABORATORY INVESTIGATION, 2017, 97 : 382A - 382AVaghefi, Amineli论文数: 0 引用数: 0 h-index: 0机构: Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USAAgarwal, Nitin K.论文数: 0 引用数: 0 h-index: 0机构: Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USAKunkalla, Kranthi论文数: 0 引用数: 0 h-index: 0机构: Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USAKim, Chae Hwa论文数: 0 引用数: 0 h-index: 0机构: Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USATjendra, Youley论文数: 0 引用数: 0 h-index: 0机构: Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USALandgraf, Ralf论文数: 0 引用数: 0 h-index: 0机构: Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USAVega, Francisco论文数: 0 引用数: 0 h-index: 0机构: Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA
- [9] Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalkNature Communications, 7Rastislav Tamaskovic论文数: 0 引用数: 0 h-index: 0机构: University of Zurich,Department of BiochemistryMartin Schwill论文数: 0 引用数: 0 h-index: 0机构: University of Zurich,Department of BiochemistryGabriela Nagy-Davidescu论文数: 0 引用数: 0 h-index: 0机构: University of Zurich,Department of BiochemistryChristian Jost论文数: 0 引用数: 0 h-index: 0机构: University of Zurich,Department of BiochemistryDagmar C. Schaefer论文数: 0 引用数: 0 h-index: 0机构: University of Zurich,Department of BiochemistryWouter P. R. Verdurmen论文数: 0 引用数: 0 h-index: 0机构: University of Zurich,Department of BiochemistryJonas V. Schaefer论文数: 0 引用数: 0 h-index: 0机构: University of Zurich,Department of BiochemistryAnnemarie Honegger论文数: 0 引用数: 0 h-index: 0机构: University of Zurich,Department of BiochemistryAndreas Plückthun论文数: 0 引用数: 0 h-index: 0机构: University of Zurich,Department of Biochemistry
- [10] Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS-p110 crosstalkNATURE COMMUNICATIONS, 2016, 7Tamaskovic, Rastislav论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, Switzerland Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, SwitzerlandSchwill, Martin论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, Switzerland Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, SwitzerlandNagy-Davidescu, Gabriela论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, Switzerland Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, SwitzerlandJost, Christian论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, Switzerland Roche Innovat Ctr Zurich, CH-8952 Zurich, Switzerland Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, SwitzerlandSchaefer, Dagmar C.论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich, Inst Lab Anim Sci, Winterthurerstr 190, CH-8057 Zurich, Switzerland Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, SwitzerlandVerdurmen, Wouter P. R.论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, Switzerland Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, SwitzerlandSchaefer, Jonas V.论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, Switzerland Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, SwitzerlandHonegger, Annemarie论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, Switzerland Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, SwitzerlandPlueckthun, Andreas论文数: 0 引用数: 0 h-index: 0机构: Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, Switzerland Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, Switzerland