Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 3. On medical care and treatment of injuries from sulfur mustard

被引：8

作者：

Timperley, Christopher M. ^{[1
]}

Forman, Jonathan E. ^{[2
,34
]}

Abdollahi, Mohammad ^{[3
,4
]}

Al-Amri, Abdullah Saeed ^{[5
]}

Baulig, Augustin ^{[6
]}

Benachour, Djafer ^{[7
]}

Borrett, Veronica ^{[8
]}

Carino, Flerida A. ^{[9
]}

Curty, Christophe ^{[10
]}

Geist, Michael ^{[11
]}

Gonzalez, David ^{[12
]}

Kane, William ^{[13
]}

Kovarik, Zrinka ^{[14
]}

Martinez-Alvarez, Roberto ^{[15
]}

Fusaro Mourao, Nicia Maria ^{[16
]}

Neffe, Slawomir ^{[17
]}

Raza, Syed K. ^{[18
]}

Rubaylo, Valentin ^{[19
]}

Graciela Suarez, Alejandra ^{[20
]}

Takeuchi, Koji ^{[21
]}

Tang, Cheng ^{[22
]}

Trifiro, Ferruccio ^{[23
]}

van Straten, Francois Mauritz ^{[24
]}

Vanninen, Paula S. ^{[25
]}

Vucinic, Slavica ^{[26
]}

Zaitsev, Volodymyr ^{[27
]}

Zafar-Uz-Zaman, Muhammad ^{[28
]}

Zina, Mongia Said ^{[29
]}

Holen, Stian ^{[30
]}

Alwan, Wesam S. ^{[31
]}

Suri, Vivek ^{[32
]}

Hotchkiss, Peter J. ^{[2
]}

Ghanei, Mostafa ^{[33
]}

机构：

[1] Def Sci & Technol Lab Dstl, OPCW SAB, Salisbury, Wilts, England

[2] OPCW, SAB, NL-2417 JR The Hague, Netherlands

[3] Univ Tehran Med Sci, Inst Pharmaceut Sci TIPS, Toxicol & Dis Grp, Sch Pharm, Tehran, Iran

[4] Univ Tehran Med Sci, Sch Pharm, Dept Toxicol & Pharmacol, Tehran, Iran

[5] Saudi Basic Ind Corp SABIC, Riyadh, Saudi Arabia

[6] Secretariat Gen Def & Securite Natl SGDSN, Paris, France

[7] Ferhat Abbas Univ Setif 1, Fac Technol, LMPMP, Setif, Algeria

[8] La Trobe Univ, La Trobe Inst Agr & Food, Melbourne, Vic 3086, Australia

[9] Univ Philippines, Quezon City, Philippines

[10] Spiez Lab, Spiez, Switzerland

[11] BASF SE, Ludwigshafen, Germany

[12] Univ Republica, Fac Quim, Montevideo, Uruguay

[13] Monsanto Co, Luling, LA USA

[14] Inst Med Res & Occupat Hlth, Zagreb, Croatia

[15] Univ Complutense Madrid, Madrid, Spain

[16] Brazilian Chem Ind, Sao Paulo, Brazil

[17] Mil Univ Technol, Warsaw, Poland

[18] Natl Accreditat Board Testing & Calibrat Labs NAB, Accreditat Comm, Gurgaon, India

[19] State Sci Res Inst Organ Chem & Technol GosNIIOKh, Moscow, Russia

[20] Univ Nacl Rosario, Consejo Nacl Invest Cient & Tecn, Rosario, Argentina

[21] Natl Inst Adv Ind Sci & Technol, Tokyo, Japan

[22] Minist Natl Def, Off Disposal Japanese Abandoned Chem Weap, Beijing, Peoples R China

[23] Univ Bologna, Dept Ind Chem, Bologna, Italy

[24] OPCW SAB, Pretoria, South Africa

[25] Univ Helsinki, Fac Sci, Dept Chem, VERIFIN, Helsinki, Finland

[26] Mil Med Acad, Natl Poison Control Ctr, Belgrade, Serbia

[27] Pontifical Catholic Univ Rio de Janeiro, Rio De Janeiro, Brazil

[28] Natl Engn & Sci Commiss NESCOM, Islamabad, Pakistan

[29] Fac Sci Tunis FST, Tunis, Tunisia

[30] OPCW, Strategy & Policy, The Hague, Netherlands

[31] Monash Univ, Monash Inst Pharmaceut Sci, Med Chem Dept, Parkville, Vic 3052, Australia

[32] OPCW Off Strategy & Policy, The Hague, Netherlands

[33] Baqiyatallah Univ Med Sci, Chem Injuries Res Ctr, Tehran, Iran

[34] Pacific Northwest Natl Lab, Global Secur Technol & Policy, Seattle, WA 98109 USA

来源：

TOXICOLOGY | 2021年 / 463卷

关键词：

Blister agent; Chemical warfare agent; Chemical weapons; Medical management; OPCW; Sulfur mustard; CHRONIC SKIN-LESIONS; WARFARE AGENT; HEMATOLOGICAL COMPLICATIONS; NITROGEN MUSTARDS; SESQUI-MUSTARD; DNA-ADDUCTS; ETHYL ETHER; GAS; EXPOSURE; HYDROLYSIS;

D O I：

10.1016/j.tox.2021.152967

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Blister agents damage the skin, eyes, mucous membranes and subcutaneous tissues. Other toxic effects may occur after absorption. The response of the Scientific Advisory Board (SAB) of the Organisation for the Prohibition of Chemical Weapons (OPCW) to a request from the OPCW Director-General in 2013 on the status of medical countermeasures and treatments to blister agents is updated through the incorporation of the latest information. The physical and toxicological properties of sulfur mustard and clinical effects and treatments are summarised. The information should assist medics and emergency responders who may be unfamiliar with the toxidrome of sulfur mustard and its treatment.

引用

页数：19

共 5 条

[1] Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 1. On medical care and treatment of injuries from nerve agents
Timperley, Christopher M.
Forman, Jonathan E.
Abdollahi, Mohammad
Al-Amri, Abdullah Saeed
Baulig, Augustin
Benachour, Djafer
Borrett, Veronica
Carino, Flerida A.
Geist, Michael
Gonzalez, David
Kane, William
Kovarik, Zrinka
Martinez-Alvarez, Roberto
Fusaro Mourao, Nicia Maria
Neffe, Slawomir
Raza, Syed K.
Rubaylo, Valentin
Graciela Suarez, Alejandra
Takeuch, Koji
Tan, Cheng
Trifiro, Ferruccio
van Straten, Francois Mauritz
Vanninen, Paula S.
Vucinic, Slavica
Zaitsev, Volodymyr
Zafar-Uz-Zaman, Muhammad
Zina, Mongia Said
Holen, Stian
TOXICOLOGY, 2019, 415 : 56 - 69
[2] Advice on chemical weapons sample stability and storage provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons to increase investigative capabilities worldwide
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Forman, Jonathan E.
Abdollahi, Mohammad
Al-Amri, Abdullah Saeed
Pascual Alonso, Isel
Baulig, Augustin
Borrett, Veronica
Carino, Flerida A.
Curty, Christophe
Gonzalez Berrutti, David
Kovarik, Zrinka
Martinez-Alvarez, Roberto
Mikulak, Robert
Fusaro Mourao, Nicia Maria
Ponnadurai, Ramasami
Neffe, Slawomir
Raza, Syed K.
Rubaylo, Valentin
Takeuchi, Koji
Tang, Cheng
Trifiro, Ferruccio
van Straten, Francois Mauritz
Vanninen, Paula S.
Zaitsev, Volodymyr
Waqar, Farhat
Zina, Mongia Said
Blum, Marc-Michael
Gregg, Hugh
Fischer, Elena
Sun, Siqing
Yang, Pei
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[3] Advice from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons on riot control agents in connection to the Chemical Weapons Convention
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Forman, Jonathan E.
Aas, Pal
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Al-Amri, Abdullah Saeed
Baulig, Augustin
Becker-Arnold, Renate
Borrett, Veronica
Carino, Flerida A.
Curty, Christophe
Gonzalez, David
Geist, Michael
Kane, William
Kovarik, Zrinka
Martinez-Alvarez, Roberto
Mikulak, Robert
Fusaro Mourao, Nicia Maria
Neffe, Slawomir
Nogueira, Evandro De Souza
Ramasami, Ponnadurai
Raza, Syed K.
Rubaylo, Valentin
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Takeuchi, Koji
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van Straten, Francois Mauritz
Suarez, Alejandra G.
Waqar, Farhat
Vanninen, Paula S.
Zafar-Uz-Zaman, Mohammad
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Zaitsev, Volodymyr
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RSC ADVANCES, 2018, 8 (73): : 41731 - 41739
[4] Advice from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons on isotopically labelled chemicals and stereoisomers in relation to the Chemical Weapons Convention
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Abdollahi, Mohammad
Al-Amri, Abdullah Saeed
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Borrett, Veronica
Carino, Flerida A.
Curty, Christophe
Gonzalez, David
Kovarik, Zrinka
Martinez-Alvarez, Roberto
Mikulak, Robert
Fusaro Mourao, Nicia Maria
Ramasami, Ponnadurai
Neffe, Slawomir
Raza, Syed K.
Rubaylo, Valentin
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PURE AND APPLIED CHEMISTRY, 2018, 90 (10) : 1647 - 1670
[5] Advice on assistance and protection from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 2. On preventing and treating health effects from acute, prolonged, and repeated nerve agent exposure, and the identification of medical countermeasures able to reduce or eliminate the longer term health effects of nerve agents
Timperley, Christopher M.
Abdollahi, Mohammad
Al-Amri, Abdullah Saeed
Baulig, Augustin
Benachour, Djafer
Borrett, Veronica
Carino, Flerida A.
Geist, Michael
Gonzalez, David
Kane, William
Kovarik, Zrinka
Martinez-Alvarez, Roberto
Fusaro Mourao, Nicia Maria
Neffe, Slawomir
Raza, Syed K.
Rubaylo, Valentin
Graciela Suarez, Alejandra
Takeuchi, Koji
Tang, Cheng
Trifiro, Ferruccio
van Straten, Francois Mauritz
Vanninen, Paula S.
Vucinic, Slavica
Zaitsev, Volodymyr
Zafar-Uz-Zaman, Muhammad
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TOXICOLOGY, 2019, 413 : 13 - 23

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