Opposite effects on the ingestion of ethanol and sucrose solutions after injections of muscimol into the nucleus accumbens shell

被引:25
|
作者
Stratford, Thomas R. [1 ]
Wirtshafter, David [1 ]
机构
[1] Univ Illinois, Lab Integrat Neurosci, Dept Psychol MC 285, Chicago, IL 60607 USA
基金
美国国家科学基金会;
关键词
Alcohol; GABA; Muscimol; Food intake; Taste; Calories; Reward; LATERAL HYPOTHALAMUS; FEEDING-BEHAVIOR; MICRODIALYSIS PROFILE; ALCOHOL-DRINKING; FOS IMMUNOREACTIVITY; GLUTAMATE RECEPTORS; INCREASES ALCOHOL; EXTENDED AMYGDALA; TASTE-AVERSIONS; NEUROPEPTIDE-Y;
D O I
10.1016/j.bbr.2010.08.032
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Injection of the GABA(A) receptor agonist muscimol into the nucleus accumbens shell (AcbSh) elicits robust feeding in satiated rats, but has no effect on water intake. The current study was designed to examine whether intra-AcbSh muscimol injections influence the intake of ethanol solutions in rats trained to drink using a limited access paradigm. We confirmed that bilateral injections of muscimol (100 ng) into the AcbSh produce large increases in the intake of sucrose solutions and of the chow maintenance diet but found in two independent experiments that these injections potently reduce the intake of a 10% ethanol solution. Furthermore, intra-AcbSh muscimol significantly increased intake of an ethanol-sucrose mixture. These results demonstrate that activating GABAA receptors in the vicinity of the AcbSh can have opposite effects on the intake of different caloric substances and are consistent with the possibility that GABAergic circuits in the AcbSh may play a role in mediating voluntary ethanol intake. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:514 / 518
页数:5
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