The flavonoid from Polygonum perfoliatum L. inhibits herpes simplex virus 1 infection

被引：16

作者：

Zhang, Q. -G. ^{[1
]}

Wei, F. ^{[1
,2
]}

Liu, Q. ^{[1
]}

Chen, L. -J. ^{[1
]}

Liu, Y. -Y. ^{[1
]}

Luo, F. ^{[1
]}

Xiong, H. -R. ^{[1
]}

Yang, Z. -Q. ^{[1
]}

机构：

[1] Wuhan Univ, State Key Lab Virol, Natl Lab Antiviral & Tumor Tradit Chinese Med, Inst Med Virol,Res Ctr Food & Drug Evaluat,Sch Me, Wuhan 430071, Peoples R China

[2] Hubei Univ Chinese Med, Sch Basic Med, Wuhan 430065, Peoples R China

来源：

ACTA VIROLOGICA | 2014年 / 58卷 / 04期

关键词：

herpes simplex virus 1; flavonoid; Polygonum perfoliatum L; antiviral; Hep-2; cell; mouse; IN-VITRO; TYPE-1;

D O I：

10.4149/av_2014_04_368

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Herpes simplex virus 1 (HSV-1) is one of the most prevalent human pathogens in both industrialized and developing countries. This study was performed to analyze the antiviral activity of purified flavonoid from Polygonum perfoliatum L. against HSV-1 infection in vitro and in vivo. Flavonoid showed no inhibitory effect, when treated before virus infection, but it strongly inhibited viral replication and cell-to-cell spread which was vital for the virus's propagation. The therapeutic effect of the flavonoid in treating HSV-1 induced encephalitis was also investigated in mice. A dose-dependent increase of survival rate and mean survival time (MST) were observed in the flavonoid-treated mice. These results suggested that the flavonoid may be a viable therapeutic option for recurrent HSV-1 infection.

引用

页码：368 / 373

页数：6

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