Myoglobinuria in two patients with Duchenne muscular dystrophy after treatment with zoledronate: a case-report and call for caution

被引：10

作者：

Ivanyuk, Anton ^{[1
]}

Segarra, Nuria Garcia ^{[2
]}

Buclin, Thierry ^{[1
]}

Klein, Andrea ^{[3
,4
,5
]}

Jacquier, David ^{[3
]}

Newman, Christopher J. ^{[3
]}

Bloetzer, Clemens ^{[3
,6
]}

机构：

[1] CHU Vaudois, Serv Clin Pharmacol, Lausanne Univ Hosp, Bugnon 17, CH-1011 Lausanne, Switzerland

[2] CHU Vaudois, Ctr Mol Dis, Lausanne Univ Hosp, Div Genet Med, Pierre Decker 2, CH-1011 Lausanne, Switzerland

[3] CHU Vaudois, Paediat Neurol & Neurorehabil Unit, Lausanne Univ Hosp, Pierre Decker 5, CH-1011 Lausanne, Switzerland

[4] UKBB, Pediat Neurol, Univ Childrens Hosp Basel, Basel, Switzerland

[5] Inselspital Bern, Bern, Switzerland

[6] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland

来源：

NEUROMUSCULAR DISORDERS | 2018年 / 28卷 / 10期

关键词：

Duchenne muscular dystrophy; myoglobinuria; bisphosphonates; zoledronate; BISPHOSPHONATE THERAPY; DOUBLE-BLIND; OSTEOPOROSIS; RHABDOMYOLYSIS; ALENDRONATE; CHILDREN; BOYS;

D O I：

10.1016/j.nmd.2018.08.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Rhabdomyolysis with myoglobinuria is a recognized complication of dystrophinopathies. It can be triggered by infections, exercise or volatile anesthetics. To our knowledge, it has never been reported in boys with Duchenne muscular dystrophy (DMD) after the administration of bisphosphonates. We report two patients with DMD who presented an apparent transient rhabdomyolysis with myoglobinuria after zoledronate administration. Possible mechanisms could involve hypophosphatemia, a known dose-dependent side effect of bisphosphonates, and/or direct myotoxicity of biphosphonates. Physicians and families should be aware of rhabdomyolysis with myoglobinuria as a potential uncommon side effect of bisphosphonates in DMD, in particular of zoledronate. (C) 2018 Published by Elsevier B.V.

引用

页码：865 / 867

页数：3

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