Synthesis of Modified Sterically Hindered Phenols and Investigation of Their Ability to Protect Bacterial DNA Against UVB Damage

被引：3
|
作者：
Oludina, Yu. N. [1 ]
Sazykina, M. A. [2 ]
Prazdnova, E. V. [2 ]
Sazykin, I. S. [2 ]
Khmelevtsova, L. E. [2 ]
Bukharov, S. V. [1 ]
Barsukova, T. A. [1 ]
Tagasheva, R. G. [1 ]
Nugumanova, G. N. [1 ]
机构：
[1] Kazan Natl Res Technol Univ, Kazan 420015, Tatarstan, Russia
[2] South Fed Univ, Res Inst Biol, Rostov Na Donu 344006, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2015年 / 48卷 / 12期
关键词：
sterically hindered phenols; UV radiation; protective activity;
D O I：
10.1007/s11094-015-1196-x
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New derivatives of sterically hindered phenols were obtained. Their DNA-protective activity under UV irradiation was studied. The experimental results showed that the investigated compounds protected genetic material from both direct UVB radiation and reactive oxygen species generated in the cell by it. The new compounds were promising components for preparations that protect DNA from UV-radiation-induced damage.
引用
收藏
页码：787 / 790
页数：4
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