Association between SNCA rs2736990 polymorphism and Parkinson's disease: a meta-analysis

Emerging evidence suggests that the SNP rs2736990 of SNCA is a susceptibility factor for idiopathic Parkinson's disease (PD) in different populations, but the studies which examined the association have provided inconsistent results. Therefore, we performed a meta-analysis of some case-control studies to obtain a more exact estimation of there associations. All the relevant studies were extracted from PubMed, Embase, EBSCO, Chineses national knowledge infrastructure, Google Scholar and Wanfang databases (up to February 2017). A total of six studies with 2525 PD cases and 2165 controls were eventually enrolled in the present meta-analysis based on the strict inclusion and exclusion criteria. The pooled analysis showed that there is a significant association between rs2736990 polymorphism and PD susceptibility in all genetic models (T vs. C: OR = 0.772, 95%CI: 0.709-0.840, P = 0.001; TT vs. CC: OR = 0.586, 95%CI: 0.490-0.701, P = 0.001; TC vs. CC: OR = 0.814, 95%CI: 0.716-0.925, P = 0.002; TT + TC vs. CC: OR = 0.752, 95%CI: 0.666-0.848, P = 0.001; 'PT vs. TC + CC: OR = 0.658, 95%CI: 0.561-0.772, P = 0.001). Our meta-analysis provides evidence that the T allele, TT and TC genotype of rs2736990(C/T) polymorphism may decrease the risk of PD.