Pharmacological Inhibition of the Pseudomonas aeruginosa MvfR Quorum-Sensing System Interferes with Biofilm Formation and Potentiates Antibiotic-Mediated Biofilm Disruption

被引:61
|
作者
Maura, Damien [1 ]
Rahme, Laurence G. [1 ]
机构
[1] Harvard Med Sch, Dept Surg, Boston, MA 02115 USA
关键词
MvfR; PqsR; biofilm; antibiotic tolerance; antibiotic adjuvant; antibiotic potentiation; Pseudomonas aeruginosa; M64; antivirulence; BACTERIAL BIOFILMS; INFECTIONS; CULTURES; RELEASE;
D O I
10.1128/AAC.01362-17
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Pseudomonas aeruginosa biofilms contribute to its survival on biotic and abiotic surfaces and represent a major clinical threat due to their high tolerance to antibiotics. Therefore, the discovery of antibiofilm agents may hold great promise. We show that pharmacological inhibition of the P. aeruginosa quorum-sensing regulator MvfR (PqsR) using a benzamide-benzimidazole compound interferes with biofilm formation and potentiates biofilm sensitivity to antibiotics. Such a strategy could have great potential against P. aeruginosa persistence in diverse environments.
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页数:5
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