Host-guest Complexation Behavior of Nardosinone and Water-soluble Phosphate Salt Pillar [6] arenet

被引：0

作者：

Yang Ju ^{[1
]}

Su Lijiao ^{[1
]}

Li Canhua ^{[1
]}

Lu Jiajia ^{[1
]}

Yang Junli ^{[1
]}

Gu Jie ^{[1
]}

Yang Li ^{[1
]}

Yang Lijuan ^{[1
]}

机构：

[1] Yunnan Minzu Univ, Sch Chem & Environm, Key Lab Intelligent Supramol Chem Univ Yunnan Pro, Natl & Local Joint Engn Res Ctr Green Preparat Te, Kunming 650500, Yunnan, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2021年 / 42卷 / 10期

基金：

中国国家自然科学基金;

关键词：

PINOCEMBRIN;

D O I：

10.7503/cjcu20200897

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using water-soluble phosphate salt pillar 6Iarene(WP6P) as the host and the natural drug nardosinone ( ND) as the guest, the saturated solution method was used to construct a new the host -guest inclusion compound of ND/WP6P. The complexation behavior between the host and guest was studied by UV spectrometric titration. The results showed that ND and WP6P formed inclusion compound at a molar ratio of 1: 1, and the complex constant was 5.160x104 limol. Infrared spectroscopy ( UR), X-ray powder diffraction ( XRD), thermos gravimetry (TG), differential thermal analysis ( DSC) and scanning electron microscope (SEM) were used to characterize the ND/WP6P inclusion compound. The possible inclusion mode of between ND and WP6P was further verified by nuclear magnetic resonance( 'H NMR 2D NMR) and molecular docking simulation. This study provides a theoretical reference for the application of water-soluble pillar [61 arene in natural medicine.

引用

页码：3099 / 3106

页数：8

共 29 条

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