The Functional Role of Oncogenic LncRNA BCAR4 for Cancer Outcome

被引：8

作者：

Wang, Bei ^{[1
]}

Xu, Wen ^{[1
]}

Cai, Yuxuan ^{[1
]}

Liu, Kai ^{[1
]}

Wu, Jiacheng ^{[1
]}

Guo, Chong ^{[1
]}

Yuan, Chengfu ^{[1
,2
,3
]}

机构：

[1] China Three Gorges Univ, Coll Med Sci, Yichang 443002, Peoples R China

[2] China Three Gorges Univ, Grade Pharmacol Lab Chinese Med 3, State Adm Tradit Chinese Med, Yichang 443002, Peoples R China

[3] China Three Gorges Univ, Hubei Key Lab Tumor Microenvironm & Immunotherapy, Yichang 443002, Peoples R China

来源：

CURRENT PHARMACEUTICAL DESIGN | 2021年 / 27卷 / 39期

关键词：

Long non-coding RNA; BCAR4; cancer; biomarkers; prognosis; NONCODING RNA BCAR4; SOLID-PHASE SYNTHESIS; GASTRIC-CANCER; PROMOTES PROLIFERATION; TAMOXIFEN RESISTANCE; CELL-PROLIFERATION; AGGRESSIVENESS; PROGRESSION; EXPRESSION; APOPTOSIS;

D O I：

10.2174/1381612827666210604114955

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Long non-coding RNA (lncRNA) breast cancer anti-estrogen resistance 4 (BCAR4) is a characterized oncogenic lncRNA in different cancers. This review is dedicated to summarize various molecular mechanisms of BCAR4 and demonstrate that the biological functions exerted by BCAR4 are good entry points for therapy. Methods: The molecular mechanism of BCAR4 acting on tumors is summarized by reviewing PubMed. Results: The expression of lncRNA BCAR4 is abnormally increased in all kinds of tumors, including colorectal cancer, prostate cancer, bladder cancer, gastric cancer, chondrosarcoma, glioma, breast cancer, glioma, gastric cancer, liver cancer, cervical cancer, lung cancer,etc. Besides, BCAR4 mediates multiple processes involved in carcinogenesis, including proliferation, invasion, anti-apoptosis, migration. Conclusion: BCAR4 may show great clinical value in this direction as a therapeutic cancer target.

引用

页码：4107 / 4113

页数：7

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