Decreased levels of the Cysteine protease inhibitor, Cystatin C, may contribute to the increased activity of Cathepsin S and an altered protein profile in tears of Sjogren's syndrome patients

被引:0
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作者
Edman, Maria C. [1 ]
Janga, Srikanth R. [1 ]
Meng, Zhen [2 ]
Bechtold, Mercy [3 ]
Chen, Alexander F. [3 ]
Kim, Chongiin [3 ]
Sarma, Arunava [3 ]
Teekappanavar, Neha [3 ]
Kim, Alice Y. [3 ]
Naman, Luke [3 ]
Madrigal, Sara [4 ]
Heur, Martin [1 ]
Christianakis, Stratos [4 ]
Arkfeld, Daniel G. [4 ]
Mack, Wendy J. [5 ]
Stohl, William [4 ,6 ]
Hamm-Alvarez, Sarah [1 ,2 ]
机构
[1] Univ Southern Calif, Keck Sch Med, USC Roski Eye Inst, Dept Ophthalmol, Los Angeles, CA USA
[2] Univ Southern Calif, Sch Pharm, Dept Pharmacol & Pharmaceut Sci, Los Angeles, CA USA
[3] Univ Southern Calif, Keck Sch Med, Los Angeles, CA USA
[4] Univ Southern Calif, Keck Sch Med, Div Rheumatol, Dept Med, Los Angeles, CA USA
[5] Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA
[6] Los Angeles Cty & Univ Southern Calif, Div Rhetunatol, Dept Med, Med Ctr, Los Angeles, CA USA
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中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
O-25
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页码:S252 / S252
页数:1
相关论文
共 16 条
  • [1] Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjogren's Syndrome patients
    Edman, Maria C.
    Janga, Srikanth R.
    Meng, Zhen
    Bechtold, Mercy
    Chen, Alexander F.
    Kim, Chongiin
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    Stohl, William
    Hamm-Alvarez, Sarah F.
    [J]. SCIENTIFIC REPORTS, 2018, 8
  • [2] Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren’s Syndrome patients
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