Waning natural and vaccine-induced immunity leading to reinfection with SARS-CoV-2 Omicron variant

被引：5
|
作者：
Shete, Anita M. [1 ]
Patil, Deepak Y. [1 ]
Sahay, Rima R. [1 ]
Sapkal, Gajanan N. [1 ]
Deshpande, Gururaj R. [1 ]
Yadav, Pragya D. [1 ]
机构：
[1] Indian Council Med Res, Natl Inst Virol, Pune, Maharashtra, India
来源：
HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2022年 / 18卷 / 06期
关键词：
SARS-CoV-2; primary infection; B.1; Covishield; reinfection; Omicron;
D O I：
10.1080/21645515.2022.2127289
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We have investigated six COVID-19 recovered cases with two doses of Covishield vaccination followed by reinfection. The primary SARS-CoV-2 infection found to occur with B.1 and reinfection with Omicron BA.1 and BA.2 variants. The genomic characterization and duration between two infections confirms these cases as SARS-CoV-2 reinfection. The immune response determined at different time intervals demonstrated boost post two dose vaccination, decline in pre-reinfection sera post 7 months and rise post reinfection. In conclusion, it was observed that these cases got SARS-CoV-2 reinfection with declined hybrid immunity acquired from primary infection and two dose covishield vaccination. This findings suggests the need to protect the community through booster dose of vaccination and prevent further infections following personal hygiene and non-pharmaceutical interventions.
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页数：3
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