Combination of statins and hormone replacement therapy in postmenopausal women is associated with increased bone mineral density

被引：19
|
作者：
De Leo, V [1 ]
Morgante, G [1 ]
la Marca, A [1 ]
Lanzetta, D [1 ]
Cobellis, L [1 ]
Petraglia, F [1 ]
机构：
[1] Univ Siena, Dept Pediat Obstet & Reprod Med, Inst Obstet & Gynecol, I-53100 Siena, Italy
来源：
GYNECOLOGICAL ENDOCRINOLOGY | 2003年 / 17卷 / 04期
关键词：
menopause; hormone replacement therapy; statins; bone mineral density;
D O I：
10.1080/713603298
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent studies have shown that statins might be potent inhibitors of bone resorption and osteoclast number, and there is evidence for their bone anabolic effects. Statin treatment seems to protect against non-pathological fractures in older women. However, contradictory findings have been obtained. In this retrospective study we found that postmenopausal women on statins and hormome replacement therapy (HRT) showed higher bone mineral density than women on HRT alone. This evidence provides further confirmation of the effect of statins on bone turnover and shows that the combination of HRT and statins reduces the risk of bone fracture by virtue of the antiresorptive effect of HRT and the anabolic and antiresorptive effects of statins.
引用
收藏
页码：329 / 332
页数：4
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