OmicsAnalyst: a comprehensive web-based platform for visual analytics of multi-omics data

被引:42
|
作者
Zhou, Guangyan [1 ]
Ewald, Jessica [2 ]
Xia, Jianguo [1 ,3 ]
机构
[1] McGill Univ, Inst Parasitol, Montreal, PQ, Canada
[2] McGill Univ, Dept Nat Resource Sci, Montreal, PQ, Canada
[3] McGill Univ, Dept Anim Sci, Montreal, PQ, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
PREGNANCY;
D O I
10.1093/nar/gkab394
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Data analysis and interpretation remain a critical bottleneck in current multi-omics studies. Here, we introduce OmicsAnalyst, a user-friendly, web-based platform that allows users to perform a wide range of well-established data-driven approaches for multi-omics integration, and visually explore their results in a clear and meaningful manner. To help navigate complex landscapes of multi-omics analysis, these approaches are organized into three visual analytics tracks: (i) the correlation network analysis track, where users choose among univariate and multivariate methods to identify important features and explore their relationships in 2D or 3D networks; (ii) the cluster heatmap analysis track, where users apply several cutting-edge multi-view clustering algorithms and explore their results via interactive heatmaps; and (iii) the dimension reduction analysis track, where users choose among several recent multivariate techniques to reveal global data structures, and explore corresponding scores, loadings and biplots in interactive 3D scatter plots. The three visual analytics tracks are equipped with comprehensive options for parameter customization, view customization and targeted analysis. OmicsAnalyst lowers the access barriers to many well-established methods for multi-omics integration via novel visual analytics.
引用
收藏
页码:W476 / W482
页数:7
相关论文
共 50 条
  • [1] OmicsNet 2.0: a web-based platform for multi-omics integration and network visual analytics
    Zhou, Guangyan
    Pang, Zhiqiang
    Lu, Yao
    Ewald, Jessica
    Xia, Jianguo
    [J]. NUCLEIC ACIDS RESEARCH, 2022, 50 (W1) : W527 - W533
  • [2] OASIS: web-based platform for exploring cancer multi-omics data
    Julio Fernandez-Banet
    Anthony Esposito
    Scott Coffin
    Istvan Boerner Horvath
    Heather Estrella
    Sabine Schefzick
    Shibing Deng
    Kai Wang
    Keith AChing
    Ying Ding
    Peter Roberts
    Paul A Rejto
    Zhengyan Kan
    [J]. Nature Methods, 2016, 13 : 9 - 10
  • [3] OASIS: web-based platform for exploring cancer multi-omics data
    Horvath, Istvan Boerner
    Estrella, Heather
    Schefzick, Sabine
    Deng, Shibing
    Wang, Kai
    AChing, Keith
    Ding, Ying
    Roberts, Peter
    Rejto, Paul A.
    Kan, Zhengyan
    [J]. NATURE METHODS, 2016, 13 (01) : 9 - 10
  • [4] Panomicon: A web-based environment for interactive, visual analysis of multi-omics data
    Osorio, Rodolfo S. Allendes
    Nystrom-Persson, Johan T.
    Nojima, Yosui
    Kosugi, Yuji
    Mizuguchi, Kenji
    Natsume-Kitatani, Yayoi
    [J]. HELIYON, 2020, 6 (08)
  • [5] A comprehensive platform for analyzing longitudinal multi-omics data
    Suhas V. Vasaikar
    Adam K. Savage
    Qiuyu Gong
    Elliott Swanson
    Aarthi Talla
    Cara Lord
    Alexander T. Heubeck
    Julian Reading
    Lucas T. Graybuck
    Paul Meijer
    Troy R. Torgerson
    Peter J. Skene
    Thomas F. Bumol
    Xiao-jun Li
    [J]. Nature Communications, 14
  • [6] A comprehensive platform for analyzing longitudinal multi-omics data
    Vasaikar, Suhas V.
    Savage, Adamk.
    Gong, Qiuyu
    Swanson, Elliott
    Talla, Aarthi
    Lord, Cara
    Heubeck, Alexander T.
    Reading, Julian
    Graybuck, Lucas T.
    Meijer, Paul
    Torgerson, Troy R.
    Skene, Peter J.
    Bumol, Thomas F.
    Li, Xiao-jun
    [J]. NATURE COMMUNICATIONS, 2023, 14 (01)
  • [7] HTT-OMNI: A Web-based Platform for Huntingtin Interaction Exploration and Multi-omics Data Integration
    Kennedy, Michelle A.
    Greco, Todd M.
    Song, Bokai
    Cristea, Ileana M.
    [J]. MOLECULAR & CELLULAR PROTEOMICS, 2022, 21 (10)
  • [8] ExpOmics: a comprehensive web platform empowering biologists with robust multi-omics data analysis capabilities
    Li, Douyue
    Min, Zhuochao
    Guo, Jia
    Chen, Yubin
    Zhang, Wenliang
    [J]. BIOINFORMATICS, 2024, 40 (08)
  • [9] MicrobioSee: A Web-Based Visualization Toolkit for Multi-Omics of Microbiology
    Li, JinHui
    Sang, Yimeng
    Zeng, Sen
    Mo, Shuming
    Zhang, Zufan
    He, Sheng
    Li, Xinying
    Su, Guijiao
    Liao, Jianping
    Jiang, Chengjian
    [J]. FRONTIERS IN GENETICS, 2022, 13
  • [10] A collaborative approach to develop a multi-omics data analytics platform for translational research
    Schumacher, Axel
    Rujan, Tamas
    Hoefkens, Jens
    [J]. APPLIED AND TRANSLATIONAL GENOMICS, 2014, 3 (04): : 105 - 108