Treatment of Refractory Crohn's Disease by Intensive Granulocyte and Monocyte Adsorption Apheresis: A Report on Two Drug Refractory Cases

被引：4
|
作者：
Kato, Shingo [1 ]
Kani, Kazuhito [1 ]
Takabayashi, Hidehiko [1 ]
Yamamoto, Ryuichi [1 ]
Ogawa, Tomonari [2 ]
Matsuda, Akihiko [2 ]
Yakabi, Koji [1 ]
机构：
[1] Saitama Med Univ, Saitama Med Ctr, Dept Gastroenterol & Hepatol, Kawagoe, Saitama, Japan
[2] Saitama Med Univ, Saitama Med Ctr, Dept Hypertens & Nephrol, Kawagoe, Saitama, Japan
来源：
INTERNAL MEDICINE | 2011年 / 50卷 / 15期
关键词：
Crohn's disease; granulocyte and monocyte adsorption apheresis; intensive therapy; ULCERATIVE-COLITIS; MULTICENTER; DEPLETION;
D O I：
10.2169/internalmedicine.50.5260
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Granulocyte and monocyte adsorption apheresis (GMA) is one therapeutic option for induction of remission in patients with inflammatory bowel diseases. Recently intensive GMA (2 sessions per week) was reported to be strikingly better than weekly GMA, both in remission rate and time to remission. Here we report two cases of Crohn's disease refractory to weekly GMA who responded to intensive GMA. One patient had not received immunosuppressive therapy while the other had been refractory to combination therapy with infliximab and azathioprine. Intensive GMA induced remission in these 2 patients. Intensive GMA may represent a therapeutic choice for remission induction and maintenance with infliximab.
引用
收藏
页码：1591 / 1593
页数：3
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