A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with α-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug

被引：11

作者：

Kasprzak, Artur ^{[1
]}

Dabrowski, Barttomiej ^{[1
]}

Zuchowska, Agnieszka ^{[1
]}

机构：

[1] Warsaw Univ Technol, Fac Chem, Noakowskiego Str 3, PL-00664 Warsaw, Poland

来源：

RSC ADVANCES | 2020年 / 10卷 / 39期

关键词：

SPHEROID CULTURE; DRUG; COMPLEXATION; TOXICITY; NMR; NANOPARTICLES; ENHANCEMENT; DERIVATIVES; CONJUGATE; PH;

D O I：

10.1039/d0ra03694c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Facile and efficient methods for the synthesis of the first poly(aminodamine) PAMAM G1.0 dendrimer octa-substituted with alpha-cyclodextrin and a novel ferrocenyl prodrug of doxorubicin hydrochloride are developed. This vector is non-toxic and can bind the designed ferrocenyl prodrug. It also shows a controlled drug release profile and high cytotoxicity against breast cancer cells (MCF-7), as elucidated by thein vitrobiological studies performed with an innovative cell-on-a-chip microfluidic system.

引用

页码：23440 / 23445

页数：6