The present article attempts to evaluate the earthquake resistance of a four-storey building frame. It also compares the performance of buildings with soft ground floors and different infill parameters, such as brick wall and shear wall. The Indian standard code (IS-code) of practice (IS: 1893, Part-1:2002) guidelines and methodology are used to analyze the problem. Response spectrum method, involving various modal participations, is employed to evaluate the nodal forces in the typical beam-column junctions. The frame members, infill walls and floors are tackled as rigid end joints, panel element, and diaphragms rigid in-plane, respectively. Linear elastic analysis is performed with individual floor mass and stiffness, taking into account the building as a multiple degrees of freedom system. The effect of damping and the soil criteria are also studied as per the provision of IS-code. The investigation concludes that the proper mass and stiffness distribution in multi-storied buildings will minimize the hazardous effects of seismic excitation. The mathematical model of the building finally recognized the hazardous features of Indian reinforced concrete buildings and recommends some measures to improve the seismic performance.