Triterpenoids with α-glucosidase inhibitory activity from Artemisia argyi

被引：28
|
作者：
Zhang, Lai-Bin [1 ]
Chang, Jia-Jing [1 ]
Guo, Li-Min [1 ]
Lv, Jie-Li [1 ]
机构：
[1] Xinxiang Med Univ, Sch Pharm, 601 Jin Sui Rd, Xinxiang 453003, Henan, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2020年 / 22卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Artemisia argyi; compositae; triterpenoids; alpha-glucosidase inhibitory activity; HIGH-FAT DIET; CONSTITUENTS;
D O I：
10.1080/10286020.2018.1543281
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new nordammarane-type triterpenoids, 3 beta-acetoxy-20-oxo-21-nordammaran-23-carboxylic acid methyl ester (1) and 3 beta-acetoxy-17 beta-dammaranic acid (2), along with two known cycloartane-type triterpenoids (3-4), were isolated from the petroleum ether-soluble extract of Artemisia argyi. Their structures were elucidated based on 1D and 2D NMR spectroscopic data analysis. All compounds were evaluated for their alpha-glucosidase inhibitory activity in vitro. Compounds 1-4 exhibited significant inhibitory effects on alpha-glucosidase with IC50 values ranging from 38.34 +/- 0.23 to 105.54 +/- 0.33 mu M.
引用
收藏
页码：241 / 248
页数：8
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