Thermo- and pH-sensitive hydrogels functionalized with thiol groups

被引：15
|
作者：
Pilar Montero-Rama, Maria [1 ]
Liras, Marta [2 ]
Garcia, Olga [1 ]
Quijada-Garrido, Isabel [1 ]
机构：
[1] CSIC, ICTP, Madrid 28006, Spain
[2] CSIC, IQOG, Madrid 28006, Spain
来源：
EUROPEAN POLYMER JOURNAL | 2015年 / 63卷
关键词：
Thermo-sensitive hydrogels; pH-sensitive hydrogels; Thiolated polymers; Swelling; 2-(2-METHOXYETHOXY)ETHYL METHACRYLATE; BLOCK-COPOLYMERS; QUANTUM DOTS; POLYMERS; BEHAVIOR; POLYMERIZATION; NANOPARTICLES; CONVERSION; CHAINS;
D O I：
10.1016/j.eurpolymj.2014.11.044
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Tacking into account the great potential of hydrogels bearing thiol functionalities, in this work we report the synthesis of thiolated hydrogels by free radical polymerization of (i) a thermo-responsive monomer, 2-(2-methoxyethoxy)ethyl methacrylate (MEO(2)MA); (ii) a lower ratio of a monomer having protected thiol group, 2-(acetylthio)ethyl methacrylate (AcSEMA) and (iii) a small proportion of tetraethylene glycol dimethacrylate (TEGDMA) as crosslinker. Subsequently, deprotection of thioacetate groups, by incubating the samples in basic solutions, allows obtaining hydrogels with free thiol groups. After this treatment, the pH dependence of the thiol-thiolate equilibrium makes the thermal response of novel P(MEO(2)MA-co-SEMA) strongly modulated by the pH. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：37 / 44
页数：8
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