A simple and efficient large-scale synthesis of 3-hydroxyphthalans via oxa-Pictet-Spengler reaction catalyzed by nanosilica sulfuric add

被引：25
|
作者：
Khorsandi, Zahra [1 ]
Khosropour, Ahmad Reza [1 ]
Mirkhani, Valiollah [1 ]
Mohammadpoor-Baltork, Iraj [1 ]
Moghadam, Majid [1 ]
Tangestaninejad, Shahram [1 ]
机构：
[1] Univ Isfahan, Fac Sci, Catalysis Div, Dept Chem, Esfahan 817467344, Iran
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 11期
关键词：
Phthalans; 3-Hydroxybenzyl alcohol; Aryl aldehyde; Oxa-Pictet-Spengler reaction; Nanosilica sulfuric acid; Microwave irradiation; ONE-POT SYNTHESIS; HETEROGENEOUS CATALYST; DERIVATIVES; ACID; FR198248; 1,3-DIHYDROISOBENZOFURAN; ISOBENZOFURAN; PHTHALANS; PESTACIN; AGENTS;
D O I：
10.1016/j.tetlet.2011.01.037
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Nanosilica sulfuric acid is found to be a new, powerful and reusable heterogeneous catalyst for the rapid synthesis of 3-hydroxyphthalans via condensation of aromatic aldehydes and 3-hydroxybenzyl alcohols under conventional heating and microwave irradiation. Scale-up preparation of these heterocycles is also carried out. (C) 2011 Published by Elsevier Ltd.
引用
收藏
页码：1213 / 1216
页数：4
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